Intracortical transmission of specific evoked activity across the cerebral cortex

Electroencephalography and Clinical Neurophysiology
J A Ennever

Abstract

The intracortical transmission of abnormally generated activity, like spreading depression and the direct cortical response, across the cortex is well known. In the experiments described here, the tangential transmission of a more normal type of cortical activity, the short latency response evoked by contralateral forepaw stimulation, was investigated. No evidence for tangential transmission was found from surface recordings. Various methods, such as passing polarizing currents, intravenous injection and topical application of strychnine, were used to alter the state of cortical excitation in order to induce a change in tangential transmission; none was found. The boundaries of the contralateral forepaw receiving area (CRA) appeared to be rigid, since the responses could not be induced beyond the perimeter by these manipulations of the cortex. Evoked responses in the centre of the CRA were shown to be unaffected by the excitation state of the cortex 2 mm or more away. The data support the hypothesis that the neural activity represented by the short latency surface evoked response is not transmitted laterally across the cortex and does not appear to be influenced by activity, beyond a range of about 2 mm or possibly less. The ef...Continue Reading

References

Jun 1, 1981·Electroencephalography and Clinical Neurophysiology·N A Shaw, B R Cant
Jan 1, 1976·Folia Psychiatrica Et Neurologica Japonica·T YamauchiN Kataoka

Citations

Sep 1, 1965·Electroencephalography and Clinical Neurophysiology·S Ochs, H Suzuki
Mar 1, 1968·International Journal of Neuropharmacology·L N Smolin, N N Samko
May 1, 1966·Experimental Neurology·A L Towe
Aug 29, 1955·The Journal of Physiology·W A COBBM K WRIGHT
Nov 1, 1958·Electroencephalography and Clinical Neurophysiology·P M MILNER
Jun 1, 1962·Experimental Neurology·O D CREUTZFELDTH KAPP
Nov 1, 1962·The Journal of Physiology·B D BURNS, G K SMITH
Nov 6, 1936·The Journal of Physiology·E D Adrian

Related Concepts

Muscle Rigidity
Cortex Bone Disorders
Adrenal Cortex Diseases
Study, Methodological
Reaction Time
Strychnine Assay
Intravenous Injections
Forefoot of Quadruped
Synaptic Transmission
Forepaw

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.