Intracranial and spinal metastases from eccrine mucinous carcinoma: case report

Neurosurgery
Rishi N ShethPhilip H Gutin

Abstract

Mucinous eccrine carcinoma (MEC) is a rare but distinct type of sweat gland tumor. MECs tend to recur locally, and their spread to distant organs is very uncommon. This article describes the first case of MEC metastasizing to the brain and the spine. A 45-year-old female presented with a 2-year history of a scalp mass in the occipital area with lymph node spread. She underwent excision of the mass and neck lymph node dissection. Pathology confirmed the diagnosis of MEC. Postoperatively, she received radiation to the involved areas. Four years later the patient presented with left hemiparesis and underwent craniotomy for gross total resection of the metastasis. This recurred after 2.5 years and she underwent another craniotomy for gross total resection followed by whole brain radiation. In addition, the patient had metastases to T11 vertebral body and the left C6 to 7 neural foramen. Moreover, the patient developed leptomeningeal disease in the spine. The metastases to the spine were treated with radiation therapy. The patient died 1.5 years later. Even though it is rare for MEC to spread to distant organs, physicians should be aware of the risk of metastatic invasion of the brain and spine and be vigilant about surveillance of ...Continue Reading

References

Dec 4, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·V EusebiF Giangaspero
Oct 15, 1992·Cancer·S N Snow, G T Reizner
Jan 1, 1989·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H R WolpertD A Bell
Jun 1, 1989·Genitourinary Medicine·W JeyakumarA Shanmugasundararaj
Oct 1, 1985·The American Journal of Dermatopathology·J P PilgrimM C Heng
Nov 1, 1966·Journal of Neurosurgery·J E Mincy, L C Lee
Jan 1, 1971·Archives of Dermatology·S Mendoza, E B Helwig
Mar 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·A A el-DomeiriE J Beattie
Dec 1, 1968·The Australasian Journal of Dermatology·I Robertson, G A Hunter
Aug 1, 1981·American Journal of Ophthalmology·K L CohenS Lipper
Apr 1, 1995·Gynecologic Oncology·S A GhamandeA M Hamid
Jul 1, 1995·Histopathology·M A RahillyA M Lessells
Mar 1, 1996·Ophthalmic Plastic and Reconstructive Surgery·M S WernerW Harrison
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·C UrsoA Giannini
Nov 6, 2001·Nature Immunology·B SchittekC Garbe
Apr 1, 1959·A.M.A. Archives of Surgery·Y G JACOBSONV H FITCHETT
Jun 4, 1960·Journal of the American Medical Association·R A GRANT
Oct 25, 2003·Journal of the American Academy of Dermatology·Rajat GoelMichael L Wallace
Oct 25, 2003·Journal of the American Academy of Dermatology·Christine E CabellElizabeth M Billingsley
Aug 7, 2004·The Tohoku Journal of Experimental Medicine·Tadashi TeradaMakoto Sugiura
Apr 29, 2005·Journal of the American Academy of Dermatology·Ming H JihLeonard H Goldberg
Jan 19, 2006·Ophthalmic Plastic and Reconstructive Surgery·Vikram D DurairajBita Esmaeli
Nov 23, 2006·Hematology/oncology Clinics of North America·Mark Bilsky, Michelle Smith
Sep 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Scott G SoltysSteven D Chang
Nov 14, 2007·Journal of Cancer Research and Therapeutics·Amit BahlG K Rath
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elisa GalleraniFranco Cavalli
Oct 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Ly DoBenham Badie

❮ Previous
Next ❯

Citations

Dec 29, 2020·Clinical Case Reports·Kisho OnoAkira Sasaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
M ToiA Myers
© 2021 Meta ULC. All rights reserved