Intracranial Aneurysm Biomarker Candidates Identified by a Proteome-Wide Study.

Omics : a Journal of Integrative Biology
Tanavi SharmaHemant Bhagat

Abstract

The scientific basis of intracranial aneurysm (IA) formation, its rupture and further development of cerebral vasospasm is incompletely understood. Aberrant protein expression may drive structural alterations of vasculature found in IA. Deciphering the molecular mechanisms underlying these events will lead to identification of early detection biomarkers and in turn, improved treatment outcomes. To unravel differential protein expression in three clinical subgroups of IA patients: (1) unruptured aneurysm, (2) ruptured aneurysm without vasospasm, (3) ruptured aneurysm who developed vasospasm, we performed untargeted quantitative proteomic analysis of aneurysm tissue and serum samples from three subgroups of IA patients and control subjects. Candidate molecules were then validated in a larger cohort of patients using enzyme-linked immunosorbent assay. A total of 937 and 294 proteins were identified from aneurysm tissue and serum samples, respectively. Several proteins that are known to maintain structural integrity of vasculature were found to be dysregulated in the context of aneurysm. ORM1, a glycoprotein, was significantly upregulated in both tissue and serum samples of unruptured aneurysm patients. We employed a larger cohort ...Continue Reading

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Datasets Mentioned

BETA
PXD013442

Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay
proteomic profiling
proteomic

Software Mentioned

Proteome Discoverer
SEQUEST
MASCOT
Morpheus

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