Intracranial aneurysms in sickle cell anemia: clinical and imaging findings

Journal of Neurointerventional Surgery
S Ali NabavizadehRobert W Hurst

Abstract

Cerebral aneurysm formation is one of the cerebrovascular complications of sickle cell disease. To report the clinical and imaging findings of intracerebral aneurysms and their treatment in pediatric and adult patients with sickle cell disease. Review of clinical data via chart abstraction and radiologic features at the University of Pennsylvania and Children's Hospital of Philadelphia from 2000 to 2014 and review of the literature since 1942. Nineteen patients with aneurysms (2.7%) were found in 709 imaged patients, including 1.2% of imaged children and 10.8% of adults. A total of 44 aneurysms were detected (52.6% with multiple aneurysms, overall 2.3 per patient), 35 (79.5%) in the anterior circulation and 9 in the posterior circulation (20.4%). Thirty-eight unruptured aneurysms ranging in size from 2 to 6 mm and six ruptured aneurysms ranging in size from 3 to 9 mm in diameter were found. Of the patients with ruptured aneurysms, two were treated by stent-assisted coiling, two by clipping, and one patient with coiling. In the group without a rupture, one patient was treated by coil embolization and one patient with a peripheral middle cerebral artery aneurysm was treated by aneurysmectomy. Three pediatric patients with a previ...Continue Reading

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Feb 14, 2016·Current Neurology and Neuroscience Reports·Courtney Lawrence, Jennifer Webb
Apr 19, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lori C Jordan, Michael R DeBaun
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Jul 22, 2021·Cardiovascular Engineering and Technology·Sara B KellerAmanda K W Buck

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