Abstract
Cellular schwannoma is a specific subtype of schwannoma, prone to misinterpretation as a malignant neoplasm. Involvement of the intracranial compartment by these tumours is extremely rare. We aim to characterise this clinicopathological subgroup. We identified a total of 20 cellular schwannomas with predominant intracranial involvement. The mean age of the patients at the time of surgery was 37 years (range = 16-81), with a slight female predominance (1.5:1 ratio). The most common sites were the eighth (n = 8) and fifth (n = 6) cranial nerves. Three tumours involved the anterior cranial fossa/olfactory groove, and a single case involved the glossopharyngeal nerve. All tumours met established criteria for cellular schwannoma, and were composed of interlacing fascicles of spindle cells lacking Verocay bodies with minimal Antoni B pattern and variable chronic inflammation and foamy histiocytes. Rare findings included haemosiderin deposition (n = 6), necrosis (n = 4), brisk mitotic activity (>10 mitoses per 10 high-power fields) (n = 2), focal epithelioid morphology (n = 2), myxoid areas (n = 2), neuroblastoma-like pattern (n = 1) and granular cells (n = 1). Immunohistochemical stains demonstrated expression of Schwann cell markers...Continue Reading
References
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·P LoddingG Stenman
Apr 1, 1990·Human Pathology·C K MaP A Haas
Sep 15, 1990·Cancer·W WhiteJ M Woodruff
Jan 1, 1987·Histopathology·C D FletcherP H McKee
Dec 1, 1981·The American Journal of Surgical Pathology·J M WoodruffN Martini
Mar 1, 1995·Cancer·G P CasadeiM B Wood
Mar 1, 1993·Journal of Neuropathology and Experimental Neurology·J P DeruazJ Costa
Jan 1, 1997·Acta Oto-laryngologica. Supplementum·R GrénmanJ Wennerberg
Mar 16, 2000·Clinical Neurology and Neurosurgery·G MarinielloV V Dolenc
Jan 6, 2001·The American Journal of Surgical Pathology·M E McMenamin, C D Fletcher
Feb 6, 2004·Brain Tumor Pathology·Ravindranath Tagore KoyyeSusarla Krishna Shankar
Sep 4, 2004·Minimally Invasive Neurosurgery : MIN·F EspositoE De Divitiis
Sep 2, 2005·Journal of Neuroradiology. Journal De Neuroradiologie·M SchlieterS Hähnel
Dec 10, 2008·The American Journal of Surgical Pathology·Bernd W ScheithauerRobert J Spinner
Feb 10, 2009·Clinical Neurology and Neurosurgery·Sarah A ErlichTim-Rasmus Kiehl
Aug 16, 2011·Oral and Maxillofacial Surgery·George RallisNicholas Zachariades
Feb 14, 2012·Acta Neuropathologica·Fausto J RodriguezArie Perry
Apr 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jason R KaramchandaniRobert B West
Sep 23, 2014·Nature Genetics·William LeePing Chi
Oct 13, 2014·Nature Genetics·Ming ZhangChetan Bettegowda
Nov 21, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Inga-Marie SchaeferJason L Hornick
Jan 12, 2016·The American Journal of Surgical Pathology·Jesse HartSharon W Weiss
Sep 27, 2016·Human Pathology·Erika F RodriguezFausto J Rodriguez