Intracranial drug-delivery scaffolds: biocompatibility evaluation of sucrose acetate isobutyrate gels

Toxicology and Applied Pharmacology
James LeeMichael Guarnieri

Abstract

Sucrose acetate isobutyrate (SAIB) is a water insoluble, biodegradable gel used for controlled-release oral and subcutaneous drug delivery. We investigated SAIB compatibility in the rat central nervous system (CNS) by implanting solutions of SAIB in adult and in neonatal brains. 10-15 microL solutions of SAIB gels in 0-30% ethanol were injected into the cerebral cortex of adult Fischer 344 rats. Control animals were implanted with a 10 mg biodegradable poly anhydride copolymer of poly [bis (p-carboxyphenoxy) propane] anhydride and sebacic acid (PCPP:SA). Adult rats were evaluated for signs of pain and distress, including changes in posture, facial signs, and grooming behavior. 1-2 microL solutions of SAIB gels in 15% ethanol were injected into brains of 12-24 h-old rats. Neonatal rats were evaluated for survival. Adult and neonatal brains were examined by histopathology 3-48 days after implant. Gel implants produced elliptical compression of cortical tissue, cell loss, and inflammation. Cell loss appeared to be confined to the implantation wound and associated neuronal fields. In adult rats, neurophil compression, inflammation, and cell loss appeared similar with the 10-mg PCPP:SA implants and the 10-mg SAIB implants. There was...Continue Reading

Citations

Jul 27, 2012·Therapeutic Delivery·Robert Loch MacdonaldTom Tice
Jan 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raghu Raj Singh ThakurDavid S Jones
Apr 3, 2009·Journal of Neurosurgery. Pediatrics·James L FrazierGeorge I Jallo
Feb 14, 2007·International Journal of Pharmaceutics·Min Jung KwonEun Seong Lee
Oct 6, 2012·Journal of Tissue Engineering and Regenerative Medicine·Paul Z Elias, Myron Spector
Feb 5, 2009·Journal of Biomedical Materials Research. Part a·Boris VaismanAbraham J Domb
Nov 11, 2017·Therapeutic Delivery·Hemlata Kaurav, Deepak N Kapoor
Aug 12, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·U W ThomaleG I Jallo
Nov 6, 2020·BioMed Research International·David KirmayerAmal Khoury

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.