PMID: 15334836Sep 1, 2004Paper

Intracranial elastance in isoflurane-anesthetized horses

American Journal of Veterinary Research
Robert J BrosnanT B Farver

Abstract

To determine whether high intracranial pressure (ICP) during spontaneous ventilation (SV) in anesthetized horses coincides with an increase in intracranial elastance (ie, change in ICP per unit change of intracranial volume). 6 adult horses. Anesthesia was induced and maintained in each horse for 5 hours with isoflurane at a constant dose equal to 1.2 times the minimum alveolar concentration. Direct ICP measurements were obtained by use of a strain gauge transducer inserted in the subarachnoid space, and arterial blood pressure was measured from a carotid artery. Physiologic responses were recorded after 15 minutes of normocapnic controlled ventilation (CV) and then after 10 minutes of SV. Aliquots (3 mL) of CSF were removed from each horse during SV until ICP returned to CV values. Slopes of pressure-volume curves yielded intracranial elastance. Intracranial elastance ranged from 0.2 to 3.7 mm Hg/mL after removal of the first aliquot of CSF Slopes of pressure-volume curves were largest following removal of the initial CSF aliquot, but shallow portions of curves were detected at relatively high ICPs (25 to 35 mm Hg). A second-order relationship between SV ICP and initial intracranial elastance was found. In horses anesthetized ...Continue Reading

References

Jun 1, 1988·Surgical Neurology·P A Grady, O R Blaumanis
Aug 1, 1970·Journal of Applied Physiology·K KogureR Busto
Sep 1, 1970·Archives of Neurology·J T Hoff, D J Reis
Nov 1, 1967·The American Journal of Physiology·K Shulman, G R Verdier
Mar 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·J M BeinerA B DuBois
May 17, 2002·Journal of Applied Physiology·Robert J BrosnanGregg D Kortz
Sep 13, 2002·American Journal of Veterinary Research·Robert J BrosnanGregg D Kortz
Jan 10, 2003·American Journal of Veterinary Research·Robert J BrosnanGregg D Kortz
Jan 1, 1964·The American Journal of Physiology·M REIVICH
Jul 1, 1965·The Journal of Surgical Research·T Q RICHARDSONG O PUGH

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Citations

Jun 4, 2008·American Journal of Veterinary Research·Robert J BrosnanBetsy Vaughan
Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Robert J Brosnan
Dec 24, 2018·Journal of Veterinary Internal Medicine·Beverly K SturgesRichard A LeCouteur

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