PMID: 9524091Apr 2, 1998Paper

Intracranial ependymoma in the adult patient: successful treatment with surgery and radiotherapy

Journal of Neuro-oncology
B Donahue, A Steinfeld

Abstract

Ependymoma is an uncommon intracerebral tumor in adults. Since the site of origin frequently prevents complete surgical removal, adjunctive radiotherapy is used to destroy residual disease. We present our experience in treating 10 adults with intracranial ependymoma. Five men and 5 women were treated in the past 16 years. The median age was 38 (range 24-69). All had contrast enhanced CT or MRI showing the extent of the tumor. One patient had total excision while the remainder had subtotal removal. Radiation therapy was delivered to the tumor bed with a 1-2 cm margin of normal tissue generally at 180-200 centiGray (cGy) per treatment once a day. Total dose ranged from 5400 to 7200 cGy. Two patients received experimental treatment with 100 cGy delivered twice a day for total of 6800 and 7200 cGy respectively. Four patients received initial treatment to a large field with a subsequent boost to the tumor bed. One patient received his entire course of treatment via this large field. With a median follow-up of 64 months, 7 patients are alive and free of disease while 2 died of intercurrent disease, without evidence of tumor, at 7 and 9 years following treatment. Another patient died 1 1/2 years after treatment of unknown causes. We c...Continue Reading

Citations

Jan 7, 2017·The Neuroradiology Journal·Soufiane BerhiliNoureddine Benjaafar
Apr 23, 2005·Neurosurgical Focus·Yaser A MaksoudHerbert H Engelhard
Nov 8, 2008·Current Opinion in Neurology·Roberta RudàRiccardo Soffietti
Sep 4, 2009·Pathology Oncology Research : POR·Dusan VitanovicsDénes Afra
Mar 23, 2012·Journal of Neuro-oncology·Michael C StauderBruce E Pollock
Oct 2, 2012·Neurologia i neurochirurgia polska·Arkadiusz Nowak, Andrzej Marchel
May 22, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kyu-Won ShimJoong-Uhn Choi
Oct 9, 2002·Clinical Obstetrics and Gynecology·Ron Swensen, Wolff Kirsch

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