PMID: 38211Jun 15, 1979

Intracranial heterotransplantation of human hematopoietic cells in nude mice

International Journal of Cancer. Journal International Du Cancer
M SchaadtV Diehl

Abstract

A panel of established cell lines and many primary cell specimens from lymphomas and leukemias as well as from normal lymphatic tissues were tested for tumorigenicity by intracranial heterotransplantation in nude mice. Not only lymphoma and leukemia cell lines, but also lymphoblastoid cell lines, lacking markers of malignancy, were tumorigenic in the brains of nude mice. These findings indicate that tumorigenicity following intracranial heterotransplantation in nude mice cannot be used as proof for the malignant nature of established cell lines. Heterotraplantation of primary cell specimens yielded only a few tumor takes. When primary cells were infected with exogenous Epstein-Barr virus prior to the transplantation procedure, tumorigenicity could be significantly increased. Cytogenetic evaluation of tumors growing after intracranial transplantation of human hematopoietic cells showed, in some cases, a selection of cytogenetically aberrant cell clones.

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Citations

Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·V DiehlC Boie
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G DelsolB Couret
Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·C von KalleW Feaux de Lacroix
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U KappV Diehl
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Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·C FonatschV Diehl
Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·K H McCormickJ S Stehlin
Dec 15, 1980·International Journal of Cancer. Journal International Du Cancer·M SchaadtH Kirchner
Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·H SteinV Diehl
Dec 15, 1980·International Journal of Cancer. Journal International Du Cancer·C FonatschV Diehl

Related Concepts

Antigens, Viral
Autosome Abnormalities
Clone Cells
Epstein-Barr Virus
Leukemia
Lymphoma
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental
Receptors, Antigen, B-Cell

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