PMID: 3758288Oct 1, 1986Paper

Intracranial hypertension and cerebrospinal fluid production in dogs: effects of furosemide

Experimental Neurology
T B MillerT Furuta

Abstract

A method using chronically prepared, anesthetized dogs was devised for studying the effects of treatments of intracranial hypertension induced by applying a reversible extradural mass lesion while simultaneously measuring production of cerebrospinal fluid. This was measured with a ventricular-cisternal perfusion technique in which the rate of cisternal outflow could be controlled by a pump and matched to the inflow, allowing intracranial pressure to fluctuate despite simultaneous measurement of cerebrospinal fluid formation. Elevations of intracranial pressure to the range 20 to 35 Torr were induced and maintained during perfusion, but elevations above 35 Torr would not permit continued perfusion. At normal intracranial pressure, 10 Torr or less, rates of cerebrospinal fluid formation were the same whether the outflow controlling pump or free outflow was used. Formation of cerebrospinal fluid decreased progressively as intracranial pressure increased above 20 Torr. It also decreased with time after the start of perfusion during the course of 5 h, but returned to the initial range during the control phase of subsequent experiments in the same animal. Furosemide, 3 mg kg-1, i.v., had no significant effect on rate of formation but...Continue Reading

References

May 1, 1972·Journal of the Neurological Sciences·A Sahar
Jun 1, 1983·Anesthesia and Analgesia·A A Artru
Sep 1, 1956·Clinica Chimica Acta; International Journal of Clinical Chemistry·A HEYROVSKY

❮ Previous
Next ❯

Citations

Jun 6, 2003·Brain Research·Kyoko TatebayashiYasuaki Kawai
Dec 1, 1987·Journal of Neurosurgery·H A Wilkinson
May 1, 1991·Journal of Neurochemistry·D BairamianM H Epstein
Feb 6, 2016·Fluids and Barriers of the CNS·Marc R Del Bigio, Domenico L Di Curzio
Jan 31, 2002·Anesthesiology·Kokila ThenuwaraJohnny E Brian
Feb 1, 1990·The American Journal of Physiology·C E JohansonM H Epstein
Apr 14, 2021·Nature Reviews. Neuroscience·Nanna MacAulay

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.