PMID: 3766771Oct 1, 1986Paper

Intracranial infusion of CCK-8 derivatives suppresses food intake in rats

The American Journal of Physiology
T MoriN Yanaihara

Abstract

The effects of infusions for approximately 1 wk of the synthetic COOH-terminal octapeptide of cholecystokinin (CCK-8) and its derivatives, pyroglutamyl-CCK-8 (pGlu-CCK-8) and glutaryl-CCK-8 (Glt-CCK-8), into the suprachiasmatic nucleus (SCN) of the hypothalamus of male Wistar rats on their feeding behavior under 12:12 light-dark cycle were examined. Infusion of CCK-8 (0.8 pmol/h) did not change the total daily food intake but caused slight decrease in food intake during the 12-h dark period with slight increase in the 12-h light period. Infusions of pGlu-CCK-8 (0.8 pmol/h) and Glt-CCK-8 (0.8 pmol/h) markedly reduced food intake during the 12-h dark period but had little effect in the light period and thus decreased total daily food intake. The reductions in food intake during the 12-h dark period due to infusions of the CCK-8 derivatives were greater than that due to CCK-8 infusion. Body weight changes reflected changes in food intake. CCK-8 derivatives appeared to suppress both meal size and frequency at the early part of the infusion period but reduce only meal size at the later part. Histological examination showed that infusion sites in the brain were widely damaged; however, neurons in the SCN appeared to be intact. These ...Continue Reading

Citations

Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M CovasaR C Ritter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.