Intracranial non-Langerhans cell histiocytosis presenting as an isolated intraparenchymal lesion.

Pediatric Radiology
Smitha RajaramDaniel J A Connolly

Abstract

Non-Langerhans cell histiocytosis in the absence of cutaneous or other organ involvement is very rare. A Caucasian boy age 3 years 11 months presented with episodes of recurrent right-side seizures over 2 weeks. Brain CT and MR imaging showed a single enhancing left frontal lobe lesion. Stereotactic biopsy was performed and histological examination showed diffuse infiltrate of macrophages with foamy cytoplasm. Four months later there was recurrence of seizure activity despite anti-epileptic medication and a repeat MR scan showed a persistent enhancing lesion in the left frontal lobe. Histological examination of the resection specimen resembled juvenile xanthogranuloma (JXG) involving the central nervous system. In the absence of skin lesions a diagnosis of non-Langerhans cell histiocytosis was made. The child made a full recovery following surgery with resolution of his symptoms.

References

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Citations

Apr 23, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kentaro ChibaYoshikazu Okada
May 30, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jeremy K DeischSandy D Cope-Yokoyama
Jun 25, 2013·Journal of Neurosurgery. Pediatrics·Loyola V GressotAndrew Jea
Jan 31, 2015·Journal of Neurosurgery. Pediatrics·Yohei MiyakeYukichi Tanaka
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexandros DoukasHubertus Maximilian Mehdorn
Dec 17, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sherise D FergusonIan E McCutcheon
Oct 5, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Liliana PaguraFrancisco Villarejo

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