Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study.

Investigative Ophthalmology & Visual Science
John P BerdahlR Rand Allingham

Abstract

To compare intracranial pressure (ICP) in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG; subset of POAG), and ocular hypertension (OHT) with that in subjects with no glaucoma. The study was a retrospective review of medical records of 62,468 subjects who had lumbar puncture between 1985 and 2007 at the Mayo Clinic. Of these, 57 POAG subjects, 11 NTG subjects (subset of POAG), 27 OHT subjects, and 105 control subjects met the criteria and were analyzed. A masked comparison of the relationship between ICP and other ocular and nonocular variables was performed by using univariate and multivariate analyses. ICP was significantly lower in POAG compared with age-matched control subjects with no glaucoma (9.1 +/- 0.77 mm Hg vs. 11.8 +/- 0.71 mm Hg; P < 0.0001). Subjects with NTG also had reduced ICP compared with the control subjects (8.7 +/- 1.16 mm Hg vs. 11.8 +/- 0.71 mm Hg; P < 0.01). ICP was higher in OHT than in age-matched control subjects (12.6 +/- 0.85 mm Hg vs. 10.6 +/- 0.81 mm Hg; P < 0.05). ICP is lower in POAG and NTG and elevated in OHT. ICP may play an important role in the development of POAG and NTG and in preventing the progression of OHT to POAG. Further prospective and experimental ...Continue Reading

Citations

May 16, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·John P BerdahlR Rand Allingham
Apr 2, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ruojin RenJost B Jonas
Dec 14, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luís Abegão PintoIngeborg Stalmans
Dec 31, 2009·Current Opinion in Ophthalmology·John P Berdahl, R Rand Allingham
Dec 6, 2011·Journal of Glaucoma·Lori M VenturaVittorio Porciatti
Jan 19, 2012·PloS One·Liang XuJost B Jonas
Jan 10, 2013·PloS One·David FleischmanR Rand Allingham
Mar 2, 2013·Aviation, Space, and Environmental Medicine·Giovanni TaibbiGianmarco Vizzeri
Jan 8, 2014·Progress in Retinal and Eye Research·Peter WostynPeter Paul De Deyn
Oct 12, 2013·Eye·J B Jonas, L Xu
Feb 11, 2014·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J B JonasN Wang
Jun 3, 2014·Indian Journal of Ophthalmology·Brian J Song, Joseph Caprioli
Dec 7, 2013·The British Journal of Ophthalmology·Brian MarekBrent Siesky
Feb 2, 2013·Survey of Ophthalmology·Giovanni TaibbiGianmarco Vizzeri
Jun 5, 2012·Ophthalmology·John BerdahlMike Fautsch
Jul 20, 2011·Medical Hypotheses·Peter WostynPeter Paul De Deyn
Jun 7, 2011·Ophthalmology·David FleischmanMichael Fautsch
Dec 9, 2009·Ophthalmology·Ruojin RenNingli Wang
Dec 23, 2015·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Peter WostynPeter Paul De Deyn
Oct 8, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M Töteberg-HarmsT S Dietlein
Sep 29, 2009·American Journal of Ophthalmology·John P Berdahl, R Rand Allingham
Oct 2, 2015·Journal of Ophthalmic & Vision Research·Sachin Jain, Ahmad A Aref
Jan 4, 2015·The British Journal of Ophthalmology·Jong Hyuk ParkKyu-Ryong Choi
Jun 30, 2015·Fluids and Barriers of the CNS·Peter WostynVeva De Groot
Apr 29, 2015·Experimental Eye Research·Derek M NusbaumBenjamin J Frankfort
Sep 24, 2013·Progress in Retinal and Eye Research·Sarah F JanssenArthur A B Bergen
Nov 15, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·David Fleischman, R Rand Allingham
Jan 27, 2015·Progress in Retinal and Eye Research·Jost B JonasSonghomitra Panda-Jonas
Oct 9, 2013·Experimental Eye Research·David FleischmanR Rand Allingham

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