Intracranial Pressure Is a Determinant of Sympathetic Activity

Frontiers in Physiology
E A SchmidtJean M Senard

Abstract

Intracranial pressure (ICP) is the pressure within thecranium. ICP rise compresses brain vessels and reduces cerebral blood delivery. Massive ICP rise leads to cerebral ischemia, but it is also known to produce hypertension, bradycardia and respiratory irregularities due to a sympatho-adrenal mechanism termed Cushing response. One still unresolved question is whether the Cushing response is a non-synaptic acute brainstem ischemic mechanism or part of a larger physiological reflex for arterial blood pressure control and homeostasis regulation. We hypothesize that changes in ICP modulates sympathetic activity. Thus, modest ICP increase and decrease were achieved in mice and patients with respectively intra-ventricular and lumbar fluid infusion. Sympathetic activity was gauged directly by microneurography, recording renal sympathetic nerve activity in mice and muscle sympathetic nerve activity in patients, and gauged indirectly in both species by heart-rate variability analysis. In mice (n= 15), renal sympathetic activity increased from 29.9 ± 4.0 bursts.s-1(baseline ICP 6.6 ± 0.7 mmHg) to 45.7 ± 6.4 bursts.s-1(plateau ICP 38.6 ± 1.0 mmHg) and decreased to 34.8 ± 5.6 bursts.s-1(post-infusion ICP 9.1 ± 0.8 mmHg). In patients (n= 10...Continue Reading

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Citations

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Clinical Trials Mentioned

NCT01776801

Software Mentioned

Graphpad Prism

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