Intracranial self-stimulation improves memory consolidation in rats with little training

Neurobiology of Learning and Memory
J Ruiz-MedinaP Segura-Torres

Abstract

Post-training intracranial electrical self-stimulation can improve learning and memory consolidation in rats. However, the molecular mechanisms involved are not known yet. Since previous paradigms of this kind of facilitation are relatively unsuitable to try a molecular approach, here we develop a single and short model of learning and memory facilitation by post-training self-stimulation that could make easier the research of its neural and molecular basis. Thus, three consecutive experiments were carried out to ascertain whether post-training self-stimulation is able to facilitate memory when learning consists of only a brief (5 trials) two-way active avoidance conditioning session. The results of Experiment 1 showed that it is actually possible, and that 48 h after the acquisition session is a very good time to observe the memory improvement. As a way to probe the retroactive effect of self-stimulation, in Experiment 2 we observed that the same self-stimulation treatment given to the subjects not post-training but 48 h before a single two-way active avoidance session does not improve the acquisition of conditioning. In Experiment 3, we showed that the SS facilitative effect observed 48 h after the acquisition session in Expe...Continue Reading

References

Jul 1, 1988·Behavioural Brain Research·P Segura-TorresI Morgado-Bernal
Mar 1, 1982·Canadian Journal of Psychology·D Coulombe, N White
Jan 7, 2004·Nature Reviews. Neuroscience·Raphael Lamprecht, Joseph LeDoux
Apr 20, 2005·Behavioural Brain Research·Carles Soriano-MasPilar Segura-Torres

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Citations

Sep 19, 2009·Neurobiology of Learning and Memory·Pilar Segura-TorresIgnacio Morgado-Bernal
Sep 9, 2015·Frontiers in Neuroscience·Qiang ZhangNandakumar S Narayanan
Aug 12, 2014·Behavioural Brain Research·Elisabet KádárPilar Segura-Torres
May 3, 2016·Neurosurgical Focus·Sarah K B Bick, Emad N Eskandar
Oct 28, 2016·Behavioural Brain Research·Soleil García-BritoPilar Segura-Torres
Jan 29, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mootaek RohMaan-Gee Lee

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