Abstract
Post-training intracranial electrical self-stimulation can improve learning and memory consolidation in rats. However, the molecular mechanisms involved are not known yet. Since previous paradigms of this kind of facilitation are relatively unsuitable to try a molecular approach, here we develop a single and short model of learning and memory facilitation by post-training self-stimulation that could make easier the research of its neural and molecular basis. Thus, three consecutive experiments were carried out to ascertain whether post-training self-stimulation is able to facilitate memory when learning consists of only a brief (5 trials) two-way active avoidance conditioning session. The results of Experiment 1 showed that it is actually possible, and that 48 h after the acquisition session is a very good time to observe the memory improvement. As a way to probe the retroactive effect of self-stimulation, in Experiment 2 we observed that the same self-stimulation treatment given to the subjects not post-training but 48 h before a single two-way active avoidance session does not improve the acquisition of conditioning. In Experiment 3, we showed that the SS facilitative effect observed 48 h after the acquisition session in Expe...Continue Reading
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Citations
May 13, 2008·Neuroscience·J Ruiz-MedinaP Segura-Torres
Aug 23, 2011·Behavioural Brain Research·Anton IlangoFrank W Ohl
Sep 19, 2009·Neurobiology of Learning and Memory·Pilar Segura-TorresIgnacio Morgado-Bernal
May 9, 2009·Neuroscience·G HuguetP Segura-Torres
Sep 9, 2015·Frontiers in Neuroscience·Qiang ZhangNandakumar S Narayanan
Aug 12, 2014·Behavioural Brain Research·Elisabet KádárPilar Segura-Torres
Apr 30, 2013·Behavioural Brain Research·Laura Aldavert-VeraPilar Segura-Torres
May 3, 2016·Neurosurgical Focus·Sarah K B Bick, Emad N Eskandar
Oct 28, 2016·Behavioural Brain Research·Soleil García-BritoPilar Segura-Torres
Jan 29, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mootaek RohMaan-Gee Lee
Oct 26, 2010·Genes, Brain, and Behavior·E KadarP Segura-Torres
Aug 1, 2013·Genes, Brain, and Behavior·E KádárP Segura-Torres
Aug 10, 2018·BMC Neuroscience·Elisabet KádárPilar Segura-Torres