Intracranial Transplantation of Hypoxia-Preconditioned iPSC-Derived Neural Progenitor Cells Alleviates Neuropsychiatric Defects After Traumatic Brain Injury in Juvenile Rats

Cell Transplantation
Zheng Zachory WeiShan Ping Yu

Abstract

Traumatic brain injury (TBI) is a common cause of mortality and long-term morbidity in children and adolescents. Posttraumatic stress disorder (PTSD) frequently develops in these patients, leading to a variety of neuropsychiatric syndromes. Currently, few therapeutic strategies are available to treat juveniles with PTSD and other developmental neuropsychiatric disorders. In the present investigation, postnatal day 14 (P14) Wistar rats were subjected to TBI induced by a controlled cortical impact (CCI) (velocity = 3 m/s, depth = 2.0 mm, contact time = 150 ms). This TBI injury resulted in not only cortical damages, but also posttrauma social behavior deficits. Three days after TBI, rats were treated with intracranial transplantation of either mouse iPSC-derived neural progenitor cells under normal culture conditions (N-iPSC-NPCs) or mouse iPSC-derived neural progenitor cells pretreated with hypoxic preconditioning (HP-iPSC-NPCs). Compared to TBI animals that received N-iPSC-NPCs or vehicle treatment, HP-iPSC-NPC-transplanted animals showed a unique benefit of improved performance in social interaction, social novelty, and social transmission of food preference tests. Western blotting showed that HP-iPSC-NPCs expressed significant...Continue Reading

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Citations

Aug 29, 2019·Frontiers in Cellular Neuroscience·Yunxiang ZhouYongchuan Deng
Jan 22, 2020·Neural Regeneration Research·Brooke BonsackCesar V Borlongan
May 20, 2020·Frontiers in Psychiatry·Yongbo ZhangZheng Zachory Wei
Dec 22, 2020·Frontiers in Neurology·Dana LengelRamesh Raghupathi
Apr 1, 2021·Neurochemistry International·M Azam Ali, Mozammel Haque Bhuiyan
Apr 13, 2021·Frontiers in Cellular Neuroscience·Yingying ZhaoZheng Zachory Wei
May 1, 2021·International Journal of Molecular Sciences·Katrina AlbertŠárka Lehtonen

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Methods Mentioned

BETA
transfection

Software Mentioned

ImageJ
Graph Prism

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