Intracranial versus Extracranial Symptomatic Carotid Atherosclerosis in Chinese Patients: Risk Factors, Stroke Mechanisms, and Long-Term Prognosis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Hongbing ChenJinsheng Zeng

Abstract

This study aims to investigate the clinical-radiological features and stroke mechanisms of symptomatic intracranial internal carotid artery (IICA) atherosclerosis and prognoses of patients with IICA atherosclosis, and compare these data with those from patients with symptomatic extranial carotid artery (EICA) atherosclerosis. We prospectively recruited 155 patients with symptomatic IICA or EICA atherosclerosis (stenosis ≥50% or occlusion) from 1968 Chinese patients with a first-ever ischemic stroke or transient ischemic attack. The patients were followed up for stroke recurrence, cardiovascular events, and death. There were 80 and 75 patients in the IICA and EICA groups, respectively. Multivariate logistic regression analyses showed that the patients in the IICA group were associated with hypertension (odds ratio [OR], 5.980; 95% confidence interval [CI], 1.790-19.976) and asymptomatic intracranial atherosclerosis (OR, 2.564; 95% CI, 1.222-5.377), while the patients in the EICA group were associated with smoking (OR, 2.397; 95% CI, 1.150-4.998) and contralateral EICA disease (OR, 4.742; 95% CI, 1.455-15.455). Hemodynamic stroke alone was more common in the IICA group; artery-to-artery embolism was identified more often in the E...Continue Reading

References

Aug 15, 1991·The New England Journal of Medicine·North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·L R WechslerM J Kaminski
Jan 1, 1983·European Neurology·J Bogousslavsky, F Regli
Nov 1, 1983·Stroke; a Journal of Cerebral Circulation·R CoteD W Taylor
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·D J MarzewskiG Williams
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·D R CraigA J Fox
Jun 20, 1998·Neurology·L TatuH Duvernoy
Mar 8, 2008·Stroke; a Journal of Cerebral Circulation·Vladimir Hachinski
May 27, 2009·Cerebrovascular Diseases·Fred RinconMitchell S V Elkind
Jan 13, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Junya AokiYuki Sakamoto
Feb 18, 2011·Internal Medicine·Toshiyasu OgataYasushi Okada
May 10, 2012·Stroke; a Journal of Cerebral Circulation·Daniel BosMeike W Vernooij
Jul 24, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Georgios TsivgoulisCharitomeni Piperidou
Oct 19, 2012·Neuroepidemiology·Matthew L FlahertyDawn Kleindorfer
Sep 7, 2013·Lancet·Adnan I Qureshi, Louis R Caplan
Nov 21, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·María Hernández-PérezAntoni Dávalos

Citations

May 6, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Jong S KimBum J Kim
Apr 10, 2020·Advances in Therapy·Marina Petrova KrastevaMirjam Rachel Heldner

Related Concepts

Brain
Internal Carotid Artery Diseases
External Carotid Artery Structure
Internal Carotid Artery Structure
Optical Image Reconstruction
Longitudinal Survey
Magnetization Transfer Contrast Imaging
Spearman Rank Correlation Coefficient
Perfusion Magnetic Resonance Imaging
Acute Cerebrovascular Accidents

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