Intractable Generalized Epilepsy: Therapeutic Approaches

Current Neurology and Neuroscience Reports
Sean T HwangSimona V Proteasa

Abstract

To summarize recent developments in therapeutic options, both medical and surgical, for patients with drug-resistant generalized epilepsy syndromes, which continue to be a multifaceted challenge for patients and physicians. Newer generation pharmaceutical options are now available, such as brivaracetam, rufinamide, lacosamide, perampanel, and cannabidiol. Less restrictive dietary options appear to be nearly as effective as classic ketogenic diet for amelioration of seizures. The latest implantable devices include responsive neurostimulation and deep brain stimulation. Corpus callosotomy is an effective treatment for some seizure types, and newer and less invasive approaches are being explored. Resective surgical options have demonstrated success in carefully selected patients despite generalized electrographic findings on electroencephalogram. The current literature reflects a widening range of clinical experience with newer anticonvulsant medications including cannabinoids, dietary therapies, surgical approaches, and neurostimulation devices for patients with intractable generalized epilepsy.

References

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Citations

Sep 15, 2020·Expert Opinion on Drug Delivery·Mihika ShringarpureAbdelwahab Omri
Apr 8, 2020·Frontiers in Behavioral Neuroscience·Jerónimo AuzmendiAlberto Lazarowski
Oct 19, 2021·Frontiers in Veterinary Science·Daisuke HasegawaShinichi Kanazono
Apr 20, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Clint A BadgerBenjamin C Kennedy

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