PMID: 8962742Sep 1, 1996Paper

Intractable hiccup in two severely handicapped patients during phenytoin therapy

No to hattatsu. Brain and development
M Nishimura

Abstract

Two severely handicapped patients developed intractable hiccup during phenytoin therapy. In these two patients, serum phenytoin levels revealed 32.6 micrograms/ml and 17.6 micrograms/ml, respectively. Since large doses of phenytoin cause delayed latencies, and depressed or lost of brainstem auditory evoked potentials, it can be speculated that intractable hiccup could occur through dysfunction of brainstem by phenytoin.

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