Intracutaneous injection of the macrophage-activating lipopeptide-2 (MALP-2) which accelerates wound healing in mice--a phase I trial in 12 patients

Experimental Dermatology
Margarete NiebuhrThomas Werfel

Abstract

Chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, are a challenge to physicians and medical personnel and a cause of tremendous discomfort and ensuing loss of quality of life to the patients. Wound healing involves production and action of various growth factors. A novel approach, distinct from the application of single growth factors, is the administration of the macrophage stimulator macrophage-activating lipopeptide-2 (MALP-2). The rationale is based on the finding that macrophages are the main source of several growth factors required for wound healing, which are sequentially released during this process. MALP-2 has previously been shown to be effective in an established animal model with diabetic mice. The purpose of the present phase I study was to establish tolerability of MALP-2 when applied into small cutaneous wounds in human beings. Twelve patients (six females and six males; mean age 66.8 years; range 52-87 years) with different diagnoses were enrolled into the study. An artificial wound was created with a 2-mm diameter skin biopsy punch and a volume of 30 microl MALP-2 (0.125-1 microg) or vehicle control, respectively, was injected intracutaneously into the wound and closed with a wa...Continue Reading

References

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Citations

Dec 3, 2010·PloS One·Martina BarrenscheeStefan Uhlig
Dec 27, 2013·Brain : a Journal of Neurology·David P StirlingPeter Stys
Oct 1, 2011·Microbial Biotechnology·Rimma LibanovaCarlos A Guzmán
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Emi KannoMasahiro Tachi
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May 20, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert J SnyderMarissa J Carter
Apr 27, 2017·Experimental Neurology·Nicole S StiversDavid P Stirling
Jul 29, 2020·International Journal of Molecular Sciences·Elena GroppaSerena Zacchigna
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Kavya L SingampalliSundeep G Keswani
May 27, 2015·Experimental Dermatology·Rajarajan A ThandavarayanPrasanna Krishnamurthy
Jul 10, 2018·Advances in Wound Care·Jacqueline LaroucheMikaël M Martino
Aug 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tobias FritzMarcel Orth

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