PMID: 9175594May 2, 1997Paper

Intracutaneous injections of platelets cause acute pain and protracted hyperalgesia

Neuroscience Letters
M SchmelzH O Handwerker

Abstract

Suspensions of autologous, washed platelets were intracutaneously injected at the volar forearms of healthy volunteers. Injections of serum and vehicle served as control. Subjects and experimenter were blind with respect to the sequence of injections. In contrast to serum and solvent solution, platelets induced graded burning pain lasting several minutes. Platelet but not serum or vehicle injections dose-dependently caused large axon-reflex flares. At the site of platelet injections an induration developed and in parallel delayed mechanical and heat hyperalgesia was observed. Hyperalgesia to pressure and impact stimulation reached a maximum after 6 h and subsided during the following 48 h. Also, the threshold to heat stimuli decreased moderately by about 1 degree C, on average, after 24 h. Neither indurations nor hyperalgesia could be detected at the injection sites of serum or vehicle. The pathophysiological significance of this new inflammatory model for the research of posttraumatic hyperalgesia is discussed.

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Citations

Jul 29, 2011·Journal of Thrombosis and Haemostasis : JTH·K M YamashitaM L Santoro
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jiang-Hong SunXin-Ping Li
May 26, 2005·Brain Research. Brain Research Reviews·Lars Edvinsson, Rolf Uddman
Jun 1, 2010·European Journal of Pain : EJP·James A BlunkMartin Schmelz
Sep 20, 2011·Journal of Vascular and Interventional Radiology : JVIR·Dean A NakamotoJohn R Haaga
Dec 1, 1998·The Journal of Physiology·K A MooreD Weinreich
Mar 28, 2017·Journal of Thrombosis and Haemostasis : JTH·K BekőB Sperlágh
Jun 5, 2003·Clinical Orthopaedics and Related Research·Masahiro KanayamaShigeru Yamane
Aug 24, 2007·Journal of Neurophysiology·Lina HerdeHermann O Handwerker
Jul 19, 2001·Annals of the New York Academy of Sciences·J C LonghurstL W Fu
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Liang-Wu Fu, John C Longhurst
Jul 29, 2021·Cell Reports Methods·Daniel M DuBreuilBrian J Wainger

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