Intracytoplasmic morphologically selected sperm injection (IMSI): a critical and evidence-based review

Basic and Clinical Andrology
A De VosH Tournaye

Abstract

Introduced in 2001, intracytoplasmic morphologically selected sperm injection (IMSI) represents a more sophisticated way of ICSI whereby, prior to injection, the spermatozoon is selected at higher magnification. Doing so, the spermatozoon can be evaluated for fine integrity of its nucleus and the injection of a normal spermatozoon with a vacuole-free head can be assured. Additional research is needed to unravel the underlying mechanisms responsible for the presence of vacuoles in sperm heads. Associations with acrosome status, chromatin condensation, DNA fragmentation and sperm aneuploidy have been documented, however, controversy on their nature exists. Spermatozoon shape and large vacuoles are detected and deselected in conventional ICSI as well. However, the detection of subtle small vacuoles depends on the resolving power of the optical system and may impact oocyte fertilization, embryo development and implantation. Several comparative studies have indicated that the use of high-magnification sperm selection was associated with both higher pregnancy and delivery rates, whereas also lower miscarriage rates were observed. However, still to date randomized, well-powered studies to confirm these findings are scarce and show con...Continue Reading

References

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Citations

Jan 18, 2015·Journal of Assisted Reproduction and Genetics·Amanda Souza SettiEdson Borges
Feb 15, 2018·Scientific Reports·Serafín Pérez-CerezalesAlfonso Gutiérrez-Adán
Nov 22, 2019·Frontiers in Cell and Developmental Biology·Felipe A NavarretePablo E Visconti
Nov 7, 2021·Nature Reviews. Urology·Erica T Y LeungPhilip C N Chiu

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