PMID: 8612860May 1, 1996Paper

Intracytoplasmic sperm injection for treatment of infertility due to acrosomal enzyme deficiency

Fertility and Sterility
M Abdul-AzizR F Casper

Abstract

To determine whether absence of fertilization in IVF associated with an acrosomal enzyme defect (hyaluronidase deficiency) results from a simple mechanical block to sperm penetration or from a more serious sperm abnormality. Nonrandomized, prospective study. Toronto Center for Advanced Reproductive Technology, a tertiary referral center for infertility associated with The University of Toronto. One hundred twenty-two couples about to undergo intracytoplasmic sperm injection (ICSI) were selected. Thirty-six of the studied couples had failed to fertilize in prior IVF cycles. Hyaluronidase activity was measured in the semen samples provided for ICSI using a zymogenic assay. Intracytoplasmic sperm injection was performed in all couples using standard techniques. Forty-eight of 122 semen samples had poor of absent semen hyaluronidase activity. All 48 samples resulted in successful fertilization with ICSI in the present study. The average fertilization rate per oocyte was 59.43% in couples in whom the partner had low semen hyaluronidase activity and 55.85% in whom the male had normal hyaluronidase activity. The ET rate per cycle was 100% and 95% and pregnancy rates per cycles were 26% and 25% in cycles with poor and normal semen hyal...Continue Reading

Citations

Dec 10, 2003·Theriogenology·Sadettin Tanyildizi, Gaffari Türk

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