Intracytoplasmic sperm injection

Molecular and Cellular Endocrinology
André Van SteirteghemI Liebaers

Abstract

Intracytoplasmic sperm injection (ICSI) with ejaculated, epididymal or testicular spermatozoa was first successful in 1992 and has since become the widely accepted treatment for couples with severe male-factor infertility. The outcome of several thousands of ICSI cycles in terms of fertilization, embryo cleavage and implantation is similar to that for conventional in-vitro fertilization in couples with tubal or idiopathic infertility. To evaluate the important issue of safety of the new technique of ICSI, a prospective follow-up study of children born after ICSI was carried out. The aim was to compile data on karyotypes, congenital malformations, growth parameters and developmental milestones. Parents' agreement to genetic counseling was obtained, as well as prenatal diagnosis, followed by a physical examination of the children at 2 months, 1 and 2 years. Important outcome data to be examined comprise information on major and minor congenital malformations obtained prenatally or after birth, as well as on the further development of the children.

References

Dec 1, 1996·Human Reproduction·P Doyle
Jan 22, 1998·Human Reproduction·M VandervorstP Devroey
May 18, 1999·Lancet·E R te VeldeR J van Kooij
May 18, 1999·Lancet·M BonduelleA Van Steirteghem
Mar 31, 2000·Human Reproduction·U B WennerholmB Källén

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Citations

Aug 20, 2004·Biology of Reproduction·Angelique Vetillard, Thierry Bailhache
Dec 13, 2019·Health Informatics Journal·Behnaz RaefReza Ferdousi
Oct 31, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S TeohR Tupprasoot
Dec 15, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gian Mario TiboniGianna Gabriella Impicciatore

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