Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

Human Vaccines & Immunotherapeutics
Yotam LevinRichard Kenney

Abstract

Intradermal immunization has become a forefront of vaccine improvement, both scientifically and commercially. Newer technologies are being developed to address the need to reduce the dose required for vaccination and to improve the reliability and ease of injection, which have been major hurdles in expanding the number of approved vaccines using this route of administration. In this review, 7 y of clinical experience with a novel intradermal delivery device, the MicronJet600, which is a registered hollow microneedle that simplifies the delivery of liquid vaccines, are summarized. This device has demonstrated both significant dose-sparing and superior immunogenicity in various vaccine categories, as well as in diverse subject populations and age groups. These studies have shown that intradermal delivery using this device is safe, effective, and preferred by the subjects. Comparison with other intradermal devices and potential new applications for intradermal delivery that could be pursued in the future are also discussed.

References

Jun 1, 1977·Journal of Clinical Pathology·P G Watson, B I Duerden
Apr 29, 1989·Lancet·M R Braddick
Jul 1, 1987·The Journal of Infectious Diseases·D B FishbeinT C Tong
Apr 22, 1972·British Medical Journal·J P StanfieldD Gall
Dec 1, 1969·The Journal of Infectious Diseases·J D Millar, W H Foege
May 1, 1969·Postgraduate Medical Journal·W L Burland
Oct 1, 1983·Journal of Biological Standardization·G DimacheT Vasilescu
Jun 21, 1995·JAMA : the Journal of the American Medical Association·J Wiström
Nov 1, 1994·Chest·P M FlynnB G Williams
Sep 22, 1994·The New England Journal of Medicine·K L NicholT Von Sternberg
May 20, 1996·Human Gene Therapy·I F CiernikD P Carbone
Nov 29, 2002·Current Drug Targets. Infectious Disorders·P J Payette, H L Davis
Jul 1, 1965·Medical History·P E RAZZELL
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin V McAllisterMark R Prausnitz
Mar 17, 2004·Advanced Drug Delivery Reviews·Mark R Prausnitz
Nov 5, 2004·The New England Journal of Medicine·Richard T KenneyGregory M Glenn
Dec 2, 2004·Applied Nursing Research : ANR·Karen Tarnow, Naomi King
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chitsanu PancharoenChristian Herzog
Oct 20, 2005·The Cochrane Database of Systematic Reviews·W Chen, C Gluud
Feb 18, 2006·The Journal of Investigative Dermatology·Ping M WangMark R Prausnitz
Sep 23, 2006·Current Topics in Microbiology and Immunology·G M Glenn, R T Kenney
Oct 3, 2006·Vaccine·Prasert AuewarakulPrasert Thongcharoen
Oct 13, 2006·Infection and Immunity·John A MiksztaRobert G Ulrich
May 20, 2008·Vaccine·Paul Henri Lambert, Philippe E Laurent
Mar 21, 2009·Human Gene Therapy·Joost H van den BergJohn B A G Haanen

❮ Previous
Next ❯

Citations

Jul 28, 2016·Expert Review of Vaccines·Corwin A RobertsonDavid P Greenberg
Feb 27, 2016·Journal of Gastroenterology and Hepatology·Amit GoelRakesh Aggarwal
Jun 13, 2017·Human Vaccines & Immunotherapeutics·Ivan F N Hung, Kwok-Yung Yuen
Sep 18, 2018·Science Advances·Darrick CarterSteven G Reed
May 1, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·N OgaiH Fukamizu
Sep 20, 2020·Vaccines·Johanna Hettinga, Robert Carlisle
Sep 15, 2020·Expert Opinion on Drug Delivery·Emrullah KorkmazLouis D Falo
Dec 15, 2019·Advanced Drug Delivery Reviews·KangJu LeeAli Khademhosseini
Sep 19, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Francisco Javier Sola MartínezRicardo Palacios Peláez
Feb 5, 2021·Advanced Drug Delivery Reviews·Emrullah KorkmazLouis D Falo
Dec 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hamed AmaniHélder A Santos
Sep 7, 2020·Advanced Drug Delivery Reviews·Anna K Polomska, Steven T Proulx
Jul 14, 2020·Vaccine·Akihiko SaitohHarunobu Hirano
Nov 14, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Ravinder K SinghF Susan Wong
Nov 9, 2021·Frontiers in Immunology·Mareike RentzschChristoph Rademacher

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Clinical Trials Mentioned

ISRCTN33950739
NCT01385566
NCT00848848
NCT01049490
NCT01304563
NCT01813604
NCT01686503

Software Mentioned

Mantoux
MicronJet
MicronJet600

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.