Intraductal papillary mucinous neoplasm of the pancreas, one manifestation of a more systemic disease?

American Journal of Surgery
Alexandra M RochC Max Schmidt

Abstract

Several studies have demonstrated a high prevalence of extrapancreatic malignancies, and an association with autoimmune pancreatitis in patients with intraductal papillary mucinous neoplasm (IPMN). We hypothesized that IPMNs were associated with an increase rate of systemic diseases. From 1996 to 2013, a retrospective analysis of a prospectively collected database was performed and supplemented with electronic medical charts review. Two hundred twenty extrapancreatic malignancies were found in 185 patients (22%) compared with expected 5% in the general population. Colorectal, lung, and renal cell carcinoma had significant observed/expected ratios (P < .0001). One hundred ten synchronous autoimmune diseases were found in 96 patients (11%). Systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease showed statistically significant observed/expected ratios (P < .0001, .01, and <.0001, respectively). There was no impact of immunosuppressive treatment on the IPMN subtype and malignancy rate. IPMN are associated with surprisingly high rates of autoimmune diseases suggesting that IPMN might be 1 manifestation of a more systemic disease.

References

Dec 6, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaUNKNOWN International Association of Pancreatology
Apr 17, 2010·World Journal of Gastroenterology : WJG·Nobuhito IkeuchiKazuhiko Kasuya
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·Jens WernerMarkus W Büchler
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaUNKNOWN International Association of Pancreatology
Apr 19, 2013·Journal of Clinical Pathology·Adrian C BatemanRunjan Chetty
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Taku TabataGunter Kloppel
Jan 1, 2014·World Journal of Gastroenterology : WJG·Takahiro UrataMichio Hifumi
Jul 27, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Eva C VaqueroXavier Molero
Apr 7, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Luigi PuglieseGüralp O Ceyhan

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