Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview

Archives of Pathology & Laboratory Medicine
Hyunsung Kim, Jae Y Ro

Abstract

Intraductal tubulopapillary neoplasm is a rare tumor that the World Health Organization recognized in 2010 as a subtype of premalignant pancreatic neoplasms. It is important to distinguish it from other intraductal neoplasms, including intraductal papillary mucinous neoplasm, pancreatic ductal adenocarcinoma, and intraductal variant of acinar cell carcinoma, because intraductal tubulopapillary neoplasm has a favorable prognosis. Histopathologically, intraductal tubulopapillary neoplasms are characterized by tubulopapillary growth, uniform high-grade cytologic atypia, frequent necrotic foci, evident ductal differentiation, and absence of mucin. Intraductal tubulopapillary neoplasms show distinct immunohistochemical and molecular findings, with positive cytokeratin 7, cytokeratin 19, MUC1, and MUC6, and somatic PIK3CA mutations (2 of 11; 18%), and low rates of KRAS (2 of 20; 10%), TP53 (5 of 22; 23%), and BRAF (2 of 13; 15%) mutations. These differences also highlight the fact that intraductal tubulopapillary pancreatic neoplasm is distinct from other similar neoplasms.

References

Oct 1, 1992·Archives of Surgery·H K ShahinianW J Lennington
Feb 17, 2005·Pancreas·Takuma TajiriToshio Morohoshi
Jun 11, 2010·The American Journal of Surgical Pathology·Daisuke BanNobuyoshi Hiraoka
Sep 29, 2011·The American Journal of Surgical Pathology·Hiroshi YamaguchiToru Furukawa
Aug 12, 2014·World Journal of Gastroenterology : WJG·Marina PainiMassimo Falconi
Mar 13, 2015·Journal of Digestive Diseases·Yukio YoshidaHiroyuki Ono
Jun 27, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna Melissa SchlitterVolkan Adsay
Nov 26, 2015·World Journal of Gastroenterology : WJG·Yaohong TanMonica T Garcia-Buitrago
Apr 30, 2016·Archives of Pathology & Laboratory Medicine·Kee-Taek Jang, Sangjeong Ahn

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Citations

Oct 1, 2018·Oncology Research and Treatment·Joo Y Kim, Seung-Mo Hong
May 29, 2021·Langenbeck's Archives of Surgery·Naziheh AssarzadeganRalph H Hruban
Aug 18, 2021·Der Pathologe·Irene EspositoMatthias M Gaida
Dec 1, 2021·Annals of Hepato-biliary-pancreatic Surgery·Jilyan DeckerOscar Kenneth Serrano

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