Intraduodenal levodopa-carbidopa intestinal gel infusion improves both motor performance and quality of life in advanced Parkinson's disease

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Florence C F ChangVictor S C Fung

Abstract

We report the efficacy and adverse effect profile of intraduodenal levodopa-carbidopa intestinal gel (LCIG) infusion from patients treated in a single Australian movement disorder centre. We conducted an open-label, 12 month prospective study of treatment with LCIG in patients with advanced Parkinson's disease in a single tertiary referral hospital unit specialising in movement disorders. Patients with levodopa-responsive, advanced Parkinson's disease with motor fluctuations despite optimal pharmacological treatment were enrolled and underwent a 16 hour daily infusion of LCIG for 12 months. Fifteen participants completed the trial. The mean (± standard deviation) improvement in Unified Parkinson's Disease Rating Scale part III was 37 ± 11%, mean daily "off" period reduced from 6.3 ± 2 to 1.9 ± 2 hours, total daily "on" time increased from 10.2 ± 3 to 13.7 ± 2 hours, "on" period without dyskinesia increased from 4.5 ± 3 to 7.5 ± 5 hours, and 39-item Parkinson's Disease Questionnaire Summary Index score improved by 32.5 ± 35%. The most common adverse event was reversible peripheral neuropathy secondary to vitamin B12 ± B6 deficiency (40%), local tube problems (40%), and impulse control disorder (ICD) (27%). No patient had stoma b...Continue Reading

References

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Citations

Sep 5, 2018·Acta Neurologica Scandinavica·Ilias ThomasDag Nyholm
Jun 1, 2019·Expert Review of Neurotherapeutics·Carmine VitaleGabriella Santangelo
Sep 2, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marie Grall-BronnecGaëlle Challet-Bouju
May 10, 2020·Acta Neurologica Scandinavica·Claas EhlersHolger Honig
Jul 18, 2020·Brain and Behavior·Walaa A Kamel, Jasem Y Al-Hashel
Jun 9, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Walter MaetzlerMalcolm Horne
Mar 28, 2017·Therapeutic Advances in Neurological Disorders·Johan Virhammar, Dag Nyholm
Mar 7, 2019·Movement Disorders Clinical Practice·Alberto RomagnoloLeonardo Lopiano
Apr 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Taiji TsunemiNobutaka Hattori

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