Intraepithelial sebaceous carcinoma of the eyelid misdiagnosed as Bowen's disease

Journal of Cutaneous Pathology
Igal LeibovitchCraig L James

Abstract

Sebaceous carcinoma (SC) is well known for its ability to masquerade clinically and histologically as a variety of periocular conditions resulting in a delayed diagnosis. We present a series of periocular SC cases and discuss the difficulties in histopathological diagnosis when this tumor presents with a Bowenoid pattern of intraepithelial spread. A retrospective case study of all patients with SC of the eyelid treated in our Hospital, from 1997 to 2004, was conducted. Eight patients were identified (four females and four males). Seven cases involved the upper eyelid. Initial clinical diagnoses included blepharitis (three cases), blepharoconjunctivitis (one case), cicatrizing conjunctivitis (one case), and lid lesions (two cases). Histopathologically, 87.5% of cases were misdiagnosed as Bowen's disease (BD) on the initial biopsy. Six of these cases showed no invasive disease on the initial biopsy and were eventually found to be invasive SC on subsequent excisions. In one case, the tumor was wholly in situ. Delay in diagnosis ranged from 0 to 56 months. SC should always be considered in the histological differential diagnosis of any eyelid lesion which resembles BD, particularly if the upper eyelid is involved or if multivacuola...Continue Reading

References

May 1, 1989·Survey of Ophthalmology·L G Kass, A Hornblass
Jan 1, 1985·Ophthalmic Plastic and Reconstructive Surgery·R P Yeatts, R R Waller
Oct 1, 1974·Archives of Ophthalmology·J A Shields, R L Font
Aug 1, 1984·The American Journal of Surgical Pathology·J T WolfeR R Waller
Feb 1, 1984·Archives of Ophthalmology·M T Doxanas, W R Green
Apr 1, 1995·Journal of Cutaneous Pathology·N ShikataA Tsubura
Jul 1, 1995·Journal of the American Academy of Dermatology·B R NelsonT M Johnson
Jan 1, 1995·Survey of Ophthalmology·C E Margo, H E Grossniklaus
Jan 16, 1998·International Ophthalmology Clinics·D H Char
Mar 21, 1998·Ophthalmology·F Gonzalez-FernandezP A Levine
Oct 27, 1999·The American Journal of Dermatopathology·I B Bayer-GarnerB Smoller
May 18, 2001·Archives of Ophthalmology·S G HonavarR C Eagle
Jul 24, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Stephen N SnowDavid D Madjar
Mar 8, 2005·Survey of Ophthalmology·Jerry A ShieldsCarol L Shields

❮ Previous
Next ❯

Citations

Mar 13, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jordan B Slutsky, Evan C Jones
Sep 17, 2013·The British Journal of Ophthalmology·Akihide WatanabeDinesh Selva
Apr 24, 2014·World Journal of Surgical Oncology·Kaoru KasedaMitsutomo Kohno
Feb 22, 2008·International Journal of Dermatology·Amina HusainBita Esmaeli
Apr 11, 2015·Journal of Maxillofacial and Oral Surgery·Irina BolmPeer W Kämmerer
Mar 4, 2017·The Journal of Dermatology·Shin-Ichi Ansai
Jul 15, 2009·Clinical & Experimental Ophthalmology·Adam K Rudkin, James S Muecke
Mar 17, 2007·Clinical & Experimental Ophthalmology·Vanessa LimawararutDinesh Selva
Oct 2, 2019·International Ophthalmology·Tatsuya YunokiAtsushi Hayashi
Jan 21, 2020·The Australasian Journal of Dermatology·Albert WuDinesh Selva
Sep 9, 2017·The Journal of Craniofacial Surgery·Paola BonavolontàLuigi Califano
Aug 5, 2020·Acta Ophthalmologica·Paula NiinimäkiMarita Uusitalo
Nov 15, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Kaustubh MulayValerie A White
Oct 31, 2013·European Journal of Ophthalmology·Yi-chen LiangHong-ge Wu
Jul 7, 2017·Current Treatment Options in Oncology·Thomas Knackstedt, Faramarz H Samie
Apr 27, 2018·International Ophthalmology·Maria Vittoria Cicinelli, Swathi Kaliki
Dec 25, 2013·The American Journal of Dermatopathology·Gabriel P CurrieGerald J Harris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

© 2022 Meta ULC. All rights reserved