Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease.

Scandinavian Journal of Immunology
T S HalstensenP Brandtzaeg

Abstract

Expression of the gamma/delta T-cell receptor (TcR) for antigen on CD3+ intraepithelial lymphocytes (IEL) was studied in situ by two-colour immunofluorescence on jejunal tissue sections from 24 patients with coeliac disease and 17 controls. The proportion of intraepithelial TcR gamma/delta+ cells was significantly increased (P less than 0.002) in untreated (median 20%, range 11-53%) as well as in treated (gluten-free diet) coeliac disease (median 23%, range 16-55%) compared with controls (median 2%, range 0-39%). Although TcR alpha/beta+ IEL dominated both in controls and coeliac disease, T cells expressing the TcR gamma/delta were preferentially located within the epithelium rather than in the lamina propria. Paired staining for TcR gamma/delta and CD8 revealed that most (approximately 90%) intraepithelial TcR gamma/delta+ lymphocytes in coeliac disease were CD8-. A remarkably large fraction (median 67%, range 58-94%) of intraepithelial TcR gamma/delta+ cells expressed the V delta 1/J delta 1-encoded epitope revealed by monoclonal antibody delta TCS1. Our results suggested that increase of the intraepithelial TcR gamma/delta+ CD8- subset of T cells is particularly related to coeliac disease.

References

Feb 1, 1989·The Journal of Clinical Investigation·J L Madara, J Stafford
Jun 1, 1989·Immunology Today·F Triebel, T Hercend
May 26, 1989·Science·J L Strominger
Jun 1, 1989·Nature·D H Raulet
Jan 1, 1989·The Journal of Experimental Medicine·L M SollidE Thorsby
Apr 1, 1988·The Journal of Experimental Medicine·T T MacDonald, J Spencer
Jun 30, 1988·Nature·C A Janeway
Mar 1, 1988·Immunology Today·C A JanewayA Hayday
Jul 10, 1986·Nature·M B BrennerM S Krangel
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane

❮ Previous
Next ❯

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·H ScottP Brandtzaeg
Jan 1, 1992·Immunologic Research·L Lefrançois
Jan 1, 1991·Immunologic Research·T S Halstensen, P Brandtzaeg
Jun 5, 2012·Seminars in Immunopathology·Valérie AbadieBana Jabri
Sep 1, 1990·Research in Immunology·H BandM B Brenner
Sep 1, 1990·Research in Immunology·J Borst, J J van Dongen
Sep 1, 1990·Research in Immunology·C RustF Koning
Jan 1, 1995·FEMS Immunology and Medical Microbiology·V NikolopoulouN Zoumbos
Sep 16, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Oberhuber
Mar 11, 1998·Current Opinion in Immunology·A Hayday, L Geng
Nov 1, 1997·Environmental Toxicology and Pharmacology·P Brandtzaeg
Nov 1, 1997·Environmental Toxicology and Pharmacology·T S Halstensen
Jul 13, 2012·Mucosal Immunology·M SarraG Monteleone
Apr 7, 1998·Clinical and Experimental Immunology·T O KerttulaM Mäki
Apr 21, 1999·Clinical and Experimental Immunology·E SavilahtiH K Akerblom
Apr 12, 2000·Clinical and Experimental Immunology·H LähteenojaS Syrjänen
Apr 12, 2000·Histopathology·C de Wolf-Peeters, R Achten
Apr 29, 1999·Scandinavian Journal of Immunology·N LahatA Lerner
Oct 25, 1990·The New England Journal of Medicine
Dec 12, 1991·The New England Journal of Medicine·J S Trier
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·S H Kaufmann
Jul 1, 1994·The Journal of Experimental Medicine·Y ChowersM F Kagnoff
Apr 29, 1998·Journal of Pediatric Gastroenterology and Nutrition·T OrmäläE Savilahti
Jun 26, 2002·Journal of Pediatric Gastroenterology and Nutrition·Paolo Lionetti
Apr 12, 2007·Journal of Clinical Gastroenterology·Alessandro UbialiGabrio Bassotti
Sep 1, 1991·Scandinavian Journal of Immunology·C J SmartL K Trejdosiewicz
Feb 1, 1991·Scandinavian Journal of Immunology·A Scheynius, L Engstrand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.