PMID: 7086712Feb 1, 1982Paper

Intraerythrocytic development of Plasmodium knowlesi: structure, temperature- and Ca2+-response of the host and parasite membranes

The Journal of protozoology
F WunderlichE Königk

Abstract

Thin-sectioning and freeze-etching electron microscopy were applied to explore the structure and the temperature- and Ca2+-response of the different host and parasite membranes during intraerythrocytic development of Plasmodium knowlesi in Macaca mulatta. The plasma membrane of uninfected erythrocytes is temperature- and Ca2+-responsive: chilling to 4 degrees C and exposure to 5 mM Ca2+ induces a slight decrease in IMP-frequency and the emergence of small IMP-devoid patches on P-faces. On parasite infection, the erythrocyte membrane becomes modified as indicated by an enhanced temperature-response and the appearance of caveolae, ca. 70-90 nm in diameter. The frequency of these caveolae is increased in schizont-infected erythrocytes. Moreover, electron dense plaques, ca. 40 nm in width, appear just beneath the erythrocyte membrane in late trophozoites and schizonts, thus indicating a further modification of the host cell membrane during parasite development. The membrane of the parasitophorous vacuole, derived from the host plasma membrane, dramatically reduces the IMP-frequency especially on the P-face upon parasite infection. This leads to an apparent reversal of the IMP-distribution persisting throughout the whole infection c...Continue Reading

References

Nov 1, 1979·The Journal of Experimental Medicine·S G Langreth, R T Reese
Nov 1, 1978·The Journal of protozoology·S G LangrethW Trager
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Schmidt-Ullrich, D F Wallach
Aug 1, 1979·Cell Biology International Reports·D F Wallach
Nov 1, 1977·The Journal of Cell Biology·Y Kitajima, G A Thompson
Aug 26, 1975·Biochemistry·F WunderlichA Blume
Dec 20, 1979·Biochimica Et Biophysica Acta·P R Cullis, B de Kruijff
May 10, 1979·Nature·A J VerkleijP H Ververgaert
Jun 13, 1979·Biochimica Et Biophysica Acta·V MelchiorD L Caspar
Jul 1, 1979·The Journal of Cell Biology·D A KirschnerD A Goodenough
Nov 15, 1977·Biochimica Et Biophysica Acta·L E King, M Morrison
Oct 15, 1974·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y Umemori-Aikawa, T Aikawa
Aug 1, 1971·Experimental Parasitology·T SeedA Johnson
May 1, 1980·Cell Biology International Reports·F WunderlichE Königk
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D E Golan, W Veatch
May 1, 1980·The Journal of Cell Biology·S W HuiT P Stewart

Citations

Jan 1, 1985·Zeitschrift Für Parasitenkunde·F WunderlichM Helwig
Feb 1, 1993·Molecular and Biochemical Parasitology·A P SimõesJ A Op den Kamp
Jun 1, 1984·Parasitology·J Pasternak, M A Fernando
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R B MikkelsenR Schmidt-Ullrich
Aug 1, 1987·The Journal of protozoology·C T AtkinsonR J Howard
Jan 1, 1986·Journal of Receptor Research·D F Wallach

Related Concepts

Calcium
Plasma Membrane
Endoplasmic Reticulum
Red Cell Ghost
Erythrocytes
Macaca mulatta
Malaria
Electron Microscopy
Nuclear Envelope
Organoids

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