Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats

American Journal of Physiology. Gastrointestinal and Liver Physiology
Chao QinRobert D Foreman

Abstract

Esophageal hypersensitivity is one of the most common causes of noncardiac chest pain in patients. In this study, we investigated whether exposure of the esophagus to acid and other chemical irritants affected activity of thoracic spinal neurons responding to esophageal distension (ED) in rats. Extracellular potentials of single thoracic (T3) spinal neurons were recorded in pentobarbital sodium-anesthetized, -paralyzed, and -ventilated male rats. ED (0.2 or 0.4 ml, 20 s) was produced by water inflation of a latex balloon placed orally into the middle thoracic region of the esophagus. The chemicals were administered via a tube that was passed through the stomach and placed in the thoracic esophagus. To irritate the esophagus, 0.2 ml of HCl (0.01 N), bradykinin (10 microg/ml), or capsaicin (10 microg/ml) were injected for 1-2 min. Only neurons excited by ED were included in this study. Results showed that intraesophageal instillation of HCl, bradykinin, and capsaicin increased activity in 3/20 (15%), 7/25 (28%), and 9/20 (45%) neurons but enhanced excitatory responses to ED in 9/17 (53%), 8/15 (53%), and 7/11 (64%) of the remaining spinal neurons, respectively. Furthermore, intraesophageal chemicals were more likely to enhance th...Continue Reading

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Citations

Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Pim W Weijenborg, Albert J Bredenoord
Apr 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chao QinRobert D Foreman
Mar 9, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shizhong ZhangShaoyong Yu
Nov 26, 2008·Autonomic Neuroscience : Basic & Clinical·Chao QinRobert D Foreman
Jul 16, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M HarringtonL Ashley Blackshaw
Nov 5, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R M SiwiecR Shaker
Nov 26, 2010·Journal of Neurogastroenterology and Motility·Hiroto MiwaJiro Watari
Mar 1, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Patrick SanvansonReza Shaker
Jul 6, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiaoyun YuShaoyong Yu
May 31, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Youtian HuShaoyong Yu
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shaoyong Yu, Ann Ouyang

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