PMID: 7545208Apr 1, 1995Paper

Intrafamilial transmission of hepatitis C virus in hemodialysis patients

Journal of Medical Virology
C H HouS C Yang

Abstract

The prevalence of hepatitis C virus (HCV) infection in chronic hemodialysis patients ranges from 20 to 50% and these patients may serve as a reservoir of infection for their household contacts. The aim of this study was to investigate the prevalence of anti-HCV in hemodialysis patients and their families, and to evaluate possible routes of infection. One hundred eighty-six family members of 84 hemodialysis patients and 529 healthy adults were enrolled. The family members consisted of 50 spouses, 96 children, 11 parents, 29 siblings, and other relatives living together with the patients. Serum samples were collected for testing anti-HCV. Exposure to risk factors was obtained by a questionnaire and an interview. The results showed that prevalence of anti-HCV in hemodialysis patients was 44%, whereas in family members it was 5.4%, not significantly different from that of age-matched healthy adults (standardized morbidity rate = 1.51, P = 0.390). The anti-HCV rate in family members tended to increase with age, and a spouse of an infected hemodialysis patient had a higher risk of HCV infection than other family members (15% vs. 2.6%, odds ratio 6.6, P = 0.058). Except for the age factor, no difference was found between seropositive ...Continue Reading

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Dec 1, 1996·Digestive Diseases and Sciences·S J Hadziyannis
Apr 28, 2004·Southern Medical Journal·Brian L Pearlman
Apr 23, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Shuang ShiHui Zhuang
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