Intraflagellar transport trains and motors: Insights from structure.

Seminars in Cell & Developmental Biology
Stephanie WebbAnthony J Roberts

Abstract

Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selectively transporting signalling molecules, IFT has critical roles in cilia biogenesis, quality control, and signal transduction. IFT involves long polymeric arrays, termed IFT trains, which move to and from the ciliary tip under the power of the microtubule-based motor proteins kinesin-II and dynein-2. Recent top-down and bottom-up structural biology approaches are converging on the molecular architecture of the IFT train machinery. Here we review these studies, with a focus on how kinesin-II and dynein-2 assemble, attach to IFT trains, and undergo precise regulation to mediate bidirectional transport.

Citations

Feb 23, 2021·Frontiers in Cell and Developmental Biology·Cassandra L BarnesPeter D Calvert
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Elena A MayDavid U Mick
May 26, 2021·Current Biology : CB·Gaia Pigino
Sep 29, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sara P AbrahamMichaela Bosakova
Nov 6, 2021·The Journal of Cell Biology·Ana R G De-CastroTiago J Dantas

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Methods Mentioned

BETA
immunoprecipitation
GTPases
ubiquitination

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