Intraganglionic laminar endings and their relationships with neuronal and glial structures of myenteric ganglia in the esophagus of rat and mouse

Histochemistry and Cell Biology
M Raab, W L Neuhuber

Abstract

Intraganglionic laminar endings (IGLEs) represent the only vagal mechanosensory terminals in the tunica muscularis of the esophagus and may be involved in local reflex control. We recently detected extensive though not complete colocalization of the vesicular glutamate transporter 2 (VGLUT2) with markers for IGLEs. To elucidate this colocalization mismatch, this study aimed at identifying markers for nitrergic, cholinergic, peptidergic, and adrenergic neurons and glial cells, which may colocalize with VGLUT2 outside of IGLEs. Confocal imaging revealed, besides substantial colocalization of VGLUT2 and substance P (SP), no other significant colocalizations of VGLUT2 and immunoreactivity for any of these markers within the same varicosities. However, we found close contacts of VGLUT2-positive structures to vesicular acetylcholine transporter, choline acetyltransferase, neuronal nitric oxide synthase, galanin, neuropeptide Y, and vasoactive intestinal peptide immunoreactive cell bodies and varicosities, as well as to glial cells. Neuronal perikarya were never positive for VGLUT2. Thus, VGLUT2 was almost exclusively found in IGLEs and may serve as a specific marker for them. In addition, many IGLEs also contained SP. The close conta...Continue Reading

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Citations

Nov 12, 2005·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Feb 25, 2005·Histochemistry and Cell Biology·Jürgen Wörl, Winfried L Neuhuber
Sep 24, 2008·Histochemistry and Cell Biology·Christine KestlerMarion Raab
Mar 3, 2012·Histochemistry and Cell Biology·Yasufumi Soda, Yoshio Yamamoto
Nov 8, 2008·Digestive Diseases and Sciences·Jingbo ZhaoHans Gregersen
Jan 23, 2016·Histochemistry and Cell Biology·Piet van der KeylenJürgen Wörl
Oct 26, 2005·Physiology & Behavior·Terry L PowleyRobert J Phillips
Aug 30, 2005·Autonomic Neuroscience : Basic & Clinical·Sophie Blat, Charles-Henri Malbert
Jun 1, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Raab, W L Neuhuber
Mar 25, 2017·Histochemistry and Cell Biology·J ZimmermannM Raab
Nov 8, 2014·The Journal of Comparative Neurology·Bao Nan ChenSimon J H Brookes
Dec 15, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Kazuhiro HoriiYasutake Shimizu
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H-R Berthoud
Oct 21, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Richard L YoungL Ashley Blackshaw
Oct 18, 2015·Histochemistry and Cell Biology·Natsumi TakahashiYoshio Yamamoto
Sep 4, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L SurdenikovaM Kollarik
Apr 11, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Azucena Perez-BurgosWolfgang A Kunze
May 24, 2006·World Journal of Gastroenterology : WJG·Jingbo ZhaoNiels Ejskjaer
Jun 8, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M HübschM Raab
Apr 4, 2021·International Journal of Molecular Sciences·Christopher KapitzaJürgen Wörl
May 26, 2021·Journal of Pharmacological Sciences·Kenjiro MatsumotoShinichi Kato

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