Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor

The American Journal of Gastroenterology
W D CheyU Murthy

Abstract

The aim of this study was to investigate whether reducing intragastric pH, at the time of urea ingestion, decreases the likelihood of false-negative (FN) urea breath test (UBT) results in patients taking a proton pump inhibitor (PPI). Patients with active Helicobacter pylori infection underwent a baseline 14C-UBT (UBT-1) followed by treatment with lansoprazole 30 mg/day for 14 to 16 days. On day 13, patients returned for a repeat standard UBT (UBT-2). Between days 14 to 16, patients underwent a modified UBT (UBT-3), which included consuming 200 ml of 0.1 N citrate solution 30 min before and at the time of 14C-urea administration. Breath samples were collected 10 and 15 min after 14C-urea ingestion. Mean 14CO2 excretion and the number of FN and equivocal UBT results were compared for the three UBTs. A total of 20 patients completed the study. Lansoprazole caused a significant decrease in mean breath 14CO2 excretion (disintegrations per minute) between UBT-1 (2.96 +/- 0.23) and UBT-2 (2.08 +/- 0.52, p < 0.05). Lansoprazole caused six (30%) FN and eight (40%) equivocal UBT-2 results. Mean breath 14CO2 excretion for UBT-3 (677 +/- 514) was greater than for UBT-2 (234 +/- 327, p = 0.001). UBT-3 caused only two (10%) FN and three (15...Continue Reading

References

Jan 15, 1998·Gastroenterology·D R ScottG Sachs
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Citations

Jul 29, 2005·Journal of Gastroenterology and Hepatology·Chander M PathakKrishan L Khanduja
Dec 1, 2004·Alimentary Pharmacology & Therapeutics·J P Gisbert, J M Pajares
Oct 13, 2006·Alimentary Pharmacology & Therapeutics·G CapursoB Annibale
Jun 18, 2003·The American Journal of Gastroenterology·David Y GrahamHala M T El-Zimaity
Jan 16, 2003·The American Journal of Gastroenterology·Haim ShirinYona Avni
Jun 3, 2009·Journal of Gastroenterology and Hepatology·Emel OztürkKemal Dağalp
Oct 24, 2002·Journal of Clinical Gastroenterology·Enzo IerardiRosario Cuomo
Feb 19, 2002·Alimentary Pharmacology & Therapeutics·D VairaM Miglioli
Apr 29, 2015·World Journal of Gastroenterology : WJG·Soumana C NasserSelim M Nasser
Jan 31, 2015·Expert Review of Molecular Diagnostics·Efrat Broide, Haim Shirin

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