Intragastric administration of Lactobacillus casei BL23 induces regulatory FoxP3+RORγt+ T cells subset in mice

Beneficial Microbes
Naima G Cortes-PerezK Adel-Patient

Abstract

Many studies have highlighted the immunomodulatory properties of the probiotic strain Lactobacillus casei BL23. Recently, we demonstrated the ability of this strain to modulate the Th2-oriented immune response in a mouse model of cow's milk allergy based on the induction of a Th17-biased immune response. The probiotic function of L. casei has been also linked to gut-microbiota modifications which could been potentially involved in the immune regulation; however, its precise mechanism of action remains poorly understood. In this regard, recent studies suggest that gut microbiota induces a specific subset of CD4+FoxP3+ Treg cells that also express RORγt+, the specific transcription factor of Th17 cells. This new type of regulatory T cells, called type 3 Treg, displays suppressive function during intestinal inflammation, participating in inflammation control. We thus explored the ability of L. casei BL23 to specifically induce type 3 Treg cells, both in vitro and in vivo. Our results showed that intragastric administration of L. casei BL23 to mice induces local and systemic FoxP3+ RORγt+ type 3 Treg cells that could then participate in the beneficial effects of L. casei BL23 in different intestinal-related disorders.

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Citations

Jan 24, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Amina ChikhiKarine Adel-Patient
May 30, 2019·Molecular Nutrition & Food Research·Daniel Lozano-OjalvoRosina López-Fandiño
Mar 6, 2018·Immune Network·Hyun Jung ParkSeokmann Hong
May 31, 2019·Journal of Immunology Research·Wenjie ZengMingyi Zhao
Aug 2, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D Lozano-OjalvoR López-Fandiño

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