Abstract
A major obstacle to development of an effective AIDS vaccine is that along with the intended beneficial responses, the immunization regimen may activate CD4+ T cells that can facilitate acquisition of human immunodeficiency virus (HIV) by serving as target cells for the virus. Lu et al. (W. Lu et al., Cell Rep 2:1736-1746, 2012, https://doi.org/10.1016/j.celrep.2012.11.016) reported that intragastric administration of chemically inactivated simian immunodeficiency virus SIVmac239 and Lactobacillus plantarum (iSIV-L. plantarum) protected 15/16 Chinese-origin rhesus macaques (RMs) from high-dose intrarectal SIVmac239 challenge at 3 months postimmunization. They attributed the observed protection to induction of immune tolerance, mediated by "MHC-Ib/E-restricted CD8+ regulatory T cells that suppressed SIV-harboring CD4+ T cell activation and ex vivo SIV replication in 15/16 animals without inducing SIV-specific antibodies or cytotoxic T." J.-M. Andrieu et al. (Front Immunol 5:297, 2014, https://doi.org/10.3389/fimmu.2014.00297) subsequently reported protection from infection in 23/24 RMs immunized intragastrically or intravaginally with iSIV and Mycobacterium bovis BCG, L. plantarum, or Lactobacillus rhamnosus, which they ascribed...Continue Reading
References
Sep 12, 1998·Journal of Virology·J L RossioJ D Lifson
Jul 20, 2002·AIDS·Binhua LingPreston A Marx
Apr 18, 2003·Current Molecular Medicine·Elena ChertovaJeffrey D Lifson
Oct 4, 2005·Nature Reviews. Immunology·Ashley T Haase
Apr 14, 2007·Science·UNKNOWN Rhesus Macaque Genome Sequencing and Analysis ConsortiumAnn S Zwieg
Feb 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter van BaarlenMichiel Kleerebezem
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
May 19, 2010·Immunogenetics·Christopher SolomonBianca R Mothé
Jan 29, 2011·Immunogenetics·Scott SouthwoodAlessandro Sette
Oct 18, 2011·Nature Biotechnology·Guangmei YanJian Wang
Oct 23, 2012·Cell Host & Microbe·Dennis R BurtonRichard Wyatt
Dec 25, 2012·Cell Reports·Wei LuJean-Marie Andrieu
Feb 19, 2013·Immunogenetics·Bianca R MothéAlessandro Sette
Aug 21, 2013·Retrovirology·Yu ZhouWen-zhe Ho
Jun 13, 2014·Journal of Virology·Suefen KwaRama Rao Amara
Jul 30, 2014·Frontiers in Immunology·Jean-Marie AndrieuWei Lu
Oct 24, 2014·Annual Review of Medicine·Jerome H KimNelson L Michael
Jan 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Diane G CarnathanGuido Silvestri
Mar 1, 2016·Cell Host & Microbe·Barton F HaynesAndrew J McMichael
Apr 28, 2016·Nature·Rajeev GautamMalcolm A Martin
May 6, 2016·Frontiers in Immunology·Wei LuJean-Marie Andrieu
Aug 19, 2016·Current Opinion in HIV and AIDS·Jean-Louis Excler, Nelson L Michael
Aug 20, 2016·Science·Jinyan LiuDan H Barouch
Sep 23, 2016·Immunity·Emily K CartwrightGuido Silvestri
Jan 31, 2017·Immunological Reviews·Mattia BonsignoriBarton F Haynes
Jan 31, 2017·Immunological Reviews·Georgia D Tomaras, Stanley A Plotkin
Jun 22, 2017·Nature·Scott G HansenLouis J Picker
Citations
Jul 26, 2018·Archives of Virology·Jean-Marie Andrieu, Wei Lu
Jan 29, 2021·Archives of Virology·Jean-Marie Andrieu, Wei Lu
Oct 13, 2021·MBio·Wilfried PoschDoris Wilflingseder