Intragastric cannulation as a method of ethanol administration for neuroendocrine studies

Alcohol
W L DeesG P Kozlowski

Abstract

A technique for implanting an intragastric cannula in the rat is described along with the usefulness of this technique for the periodic administration of ethanol (ETOH). Our results indicate that rats receiving ETOH (3.0 g/kg) every eight hours for three days exhibit approximately a 37% (p less than 0.05) depression in serum luteinizing hormone (LH) levels, with approximately a 40% (p less than 0.025) increase in serum prolactin (Prl) levels when compared with rats receiving saline only. These results are similar to those acute effects observed following multiple IP administration of ETOH; however, the intragastric route of delivery provides an animal model for studying the effects of ETOH on the hypothalamo-hypophysial-unit with only a minimum amount of stress to the animal. Advantages of this technique are discussed in comparison with other methods of ETOH administration and their effects on the hypothalamic-LH axis.

References

Jul 1, 1978·Alcoholism, Clinical and Experimental Research·T J CiceroT M Badger
Oct 1, 1979·Endocrinology·D H van ThielR Lester
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Jan 1, 1980·Alcoholism, Clinical and Experimental Research·C N MurtyH Sidransky

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Citations

Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·A LafuenteA I Esquifino
Mar 1, 1988·Alcohol·M G Subramanian, E L Abel
Apr 1, 1990·Alcoholism, Clinical and Experimental Research·M G SubramanianE L Abel
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·M G SubramanianB A Bergeski
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·V K SrivastavaW L Dees
Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaW Les Dees
Nov 27, 2015·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
Jun 13, 2009·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaW Les Dees
Jun 10, 2003·Annals of the New York Academy of Sciences·Valeria RettoriSamuel M McCann
Apr 25, 2018·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
May 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·L F Fajardo, S D Prionas

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