Intraglomerular lateral inhibition promotes spike timing variability in principal neurons of the olfactory bulb

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Marion NajacDidier De Saint Jan

Abstract

The activity of mitral and tufted cells, the principal neurons of the olfactory bulb, is modulated by several classes of interneurons. Among them, diverse periglomerular (PG) cell types interact with the apical dendrites of mitral and tufted cells inside glomeruli at the first stage of olfactory processing. We used paired recording in olfactory bulb slices and two-photon targeted patch-clamp recording in vivo to characterize the properties and connections of a genetically identified population of PG cells expressing enhanced yellow fluorescent protein (EYFP) under the control of the Kv3.1 potassium channel promoter. Kv3.1-EYFP(+) PG cells are axonless and monoglomerular neurons that constitute ∼30% of all PG cells and include calbindin-expressing neurons. They respond to an olfactory nerve stimulation with a short barrage of excitatory inputs mediated by mitral, tufted, and external tufted cells, and, in turn, they indiscriminately release GABA onto principal neurons. They are activated by even the weakest olfactory nerve input or by the discharge of a single principal neuron in slices and at each respiration cycle in anesthetized mice. They participate in a fast-onset intraglomerular lateral inhibition between principal neuron...Continue Reading

Citations

Sep 15, 2017·Physiological Reviews·Leonard K Kaczmarek, Yalan Zhang
Jul 21, 2017·Journal of Neurophysiology·Shawn D Burton
Mar 29, 2019·The Journal of Physiology·Alvaro Sanz DiezDidier De Saint Jan
Dec 15, 2015·Journal of Neurophysiology·Julia BrillMichael T Shipley
Jan 30, 2020·Journal of Neurophysiology·Fu-Wen ZhouAdam C Puche
Jul 10, 2021·Frontiers in Cellular Neuroscience·Zhenbo HuangDebra Ann Fadool

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