PMID: 11907013Mar 22, 2002Paper

Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation

Heart
Hester A de Groot-KrusemanA H Balk

Abstract

To assess whether diastolic graft function is influenced by intragraft interleukin 2 (IL-2) messenger RNA (mRNA) expression in rejecting cardiac allografts. 16 recipients of cardiac allografts were monitored during the first three months after transplantation. The presence of IL-2 mRNA in endomyocardial biopsies (n = 123) was measured by reverse transcriptase polymerase chain reaction. To determine heart function, concurrent M mode and two dimensional Doppler echocardiograms were analysed. Histological signs of acute rejection (International Society for Heart and Lung Transplantation (ISHLT) rejection grade > 2) were strongly associated with IL-2 mRNA expression (IL-2 mRNA was present in 12 of 20 endomyocardial biopsies (60%) with acute rejection and in 24 of 103 endomyocardial biopsies (23%) without acute rejection, p = 0.002). No significant relation was found between either histology or IL-2 mRNA expression alone and the studied echocardiographic parameters. However, stratification of the echocardiographic data into those of patients with and those without acute rejection showed that during acute rejection IL-2 mRNA expression was significantly associated with increased left ventricular total wall thickness (mean change in t...Continue Reading

References

Mar 1, 1992·Transplantation·M J DallmanP J Morris
Mar 15, 1995·Journal of the American College of Cardiology·E A GillE M Gilbert
Aug 1, 1997·Annals of Medicine·K J Pulkki
Dec 24, 1997·Immunopharmacology·R Baluna, E S Vitetta
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Jun 25, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·C C Baan, W Weimar

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Citations

Sep 1, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David LinUNKNOWN NCE CECR Centre of Excellence for the Prevention of Organ Failure
Dec 9, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Naoki SatodaTakaaki Koshiba
Dec 19, 2006·Transplantation Proceedings·E DijkeC Baan
Feb 3, 2005·Transplantation Proceedings·H A de Groot-KrusemanW Weimar
Feb 16, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nicole M van BesouwCarla C Baan

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