Intragranulomatous necrosis in lungs of mice infected by aerosol with Mycobacterium tuberculosis is related to bacterial load rather than to any one cytokine or T cell type

Microbes and Infection
Olga GilPere-Joan Cardona

Abstract

Low dose aerosol infection of C57BL/6 mice with a clinical strain of Mycobacterium tuberculosis (UTE 0335 R) induced intragranulomatous necrosis in pulmonary granulomas (INPG) at week 9 postinfection. Infection of different knockout (KO) mouse strains with UTE 0335 R induced INPG in all strains and established two histopathological patterns. The first pattern was seen in SCID mice and in mice with deleted alpha/beta T receptor, TNF R1, IL-12, IFN-gamma, or iNOS genes, and showed a massive INPG with a high granulomatous infiltration of the lung, a large and homogeneous eosinophilic necrosis full of acid-fast bacilli, with marked karyorrhexis, coarse basophilic necrosis, and surrounded by patches delimited by partially conserved alveolar septum full of PMNs. The second pattern was seen in mice with deleted IL-1 R1, IL-6, IL-10, CD4, CD8 or gamma/delta T cell receptor genes, and showed more discrete lesions with predominant homogeneous eosinophilic necrosis with few bacilli and surrounded by a well-defined lymphocyte-based ring. Local expression of IFN-gamma, iNOS, TNF and RANTES showed no significant differences between these mouse strains generating a discrete INPG. Mouse strains showing a massive INPG showed higher, lower or eq...Continue Reading

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Citations

Apr 1, 2011·Enfermedades infecciosas y microbiología clínica·Pere-Joan Cardona, Juraj Ivanyi
Aug 21, 2009·Nature Immunology·David G RussellFrédéric Altare
Mar 26, 2011·Clinical & Developmental Immunology·Pere-Joan Cardona
Nov 13, 2012·Medical Microbiology and Immunology·Satria A PrabowoTjip S van der Werf
Jul 16, 2013·Tuberculosis·Mercedes Gonzalez-JuarreroRichard Bowen
Apr 15, 2014·Vaccine·Matthias I GröschelTjip S van der Werf
Oct 14, 2016·Frontiers in Microbiology·Pere-Joan Cardona
Mar 2, 2016·International Journal of Molecular Sciences·Vanessa C KorbDevapregasan Moodley
Mar 5, 2009·Yonsei Medical Journal·Jinhee LeeHardy Kornfeld
Nov 27, 2018·Current Molecular Pharmacology·Manaf AlMatarFatih Köksal
Mar 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiyuan BaiEdward D Chan
Jul 18, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shachi Pranjal Vyas, Ritobrata Goswami

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