Intrahepatic Activity Distribution in Radioembolization with Yttrium-90-Labeled Resin Microspheres Using the Body Surface Area Method--A Less than Perfect Model

Journal of Vascular and Interventional Radiology : JVIR
Oliver S GrosserJuri Ruf

Abstract

To retrospectively assess the influence of the parameters of the body surface area (BSA) method in hepatic radioembolization using yttrium-90-labeled microspheres on the determination of the prescribed activity. Data from 283 consecutive patients treated with radioembolization (BSA method) were included. For interindividual comparisons, activity concentrations (ACs; MBq/mL) were calculated for each liver. The impact of the BSA method parameters was assessed by analysis of variance and pairwise t test with Bonferroni-Holm correction. Prescribed activity was 1.01-2.71 GBq, with BSA, liver volume (LV), tumor burden, and the liver-lung shunt reduction factor (LLS RF) being significant contributing factors to the AC (all P < .0001, analysis of variance). BSA and LV correlated only moderately (ρ = 0.46, P < .0001). Compared with base activity defined by the BSA (median = 1.67 GBq; range, 1.20-2.32 GBq), the activity contribution of tumor burden was small (median = 150 MBq; range, 3-800 MBq). Resulting activities were reduced according to LLS RF by 20% in 12.4% and by 40% in 3.5% of patients. AC was significantly (up to 56%) lower in association with larger LV than in small LV (LV < 1,500 mL vs ≥ 2,500 mL, P < .0001). In the BSA model...Continue Reading

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Citations

Feb 3, 2016·Journal of Vascular and Interventional Radiology : JVIR·Oliver S GrosserJuri Ruf
Mar 26, 2016·Journal of Vascular and Interventional Radiology : JVIR·Morsal SamimMarnix G E H Lam
Jun 12, 2016·Journal of Vascular and Interventional Radiology : JVIR·Nadine Abi-Jaoudeh
Mar 31, 2017·Cardiovascular and Interventional Radiology·Markus ZimmermannPhilipp Bruners
Jul 22, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Hugo LevillainPatrick Flamen
Mar 17, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marilyne KafrouniFayçal Ben Bouallègue

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