Intrahepatic Administration of Liposomal Amphotericin B (Ambisome) for the Management of a Liver Abscess from Candida albicans in a Preterm Infant

Antimicrobial Agents and Chemotherapy
Cinzia AuritiFiammetta Piersigilli

Abstract

Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (Ambisome), never described in neonates in the literature, which turned out to be a safe and effective approach.

References

Jun 1, 1977·The Journal of Pediatrics·R K MathisW A Walker
Feb 4, 2009·Acta Paediatrica·Luca FilippiPatrizio Fiorini
Aug 29, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Antonio CascioIgnazio Barberi
Mar 19, 2014·The Pediatric Infectious Disease Journal·Fiammetta PiersigilliAndrea Dotta
Sep 12, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yu-Long CaiNan-Sheng Cheng
Oct 5, 2016·Antimicrobial Agents and Chemotherapy·Cinzia AuritiManjunath P Pai
Jul 18, 2018·Antimicrobial Agents and Chemotherapy·Cinzia AuritiManjunath P Pai

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Citations

Oct 17, 2019·Frontiers in Pediatrics·Iliana BersaniCinzia Auriti
Jun 5, 2020·The Pediatric Infectious Disease Journal·Joseph B CanteyAmy F Quinn

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