Intrahepatic cholangiocarcinoma: can imaging phenotypes predict survival and tumor genetics?

Abdominal Radiology
Emily A AherneRichard K Do

Abstract

On computed tomography (CT), intrahepatic cholangiocarcinomas (ICC) are a visibly heterogeneous group of tumors. The purpose of this study was to investigate the associations between CT imaging phenotypes, patient survival, and known genetic markers. A retrospective study was performed with 66 patients with surgically resected ICC. Pre-surgical CT images of ICC were assessed by radiologists blinded to tumor genetics and patient clinical data. Associations between qualitative imaging features and overall survival (OS) and disease-free survival (DFS) were performed with Cox proportional hazards regression and visualized with Kaplan-Meier plots. Associations between radiographic features and genetic pathways (IDH1, Chromatin and RAS-MAPK) were assessed with Fisher's Exact test and the Wilcoxon Rank sum test where appropriate and corrected for multiple comparisons within each pathway using the False Discovery Rate correction. Three imaging features were significantly associated with a higher risk of death: necrosis (hazard ratio (HR) 2.95 95% CI 1.44-6.04, p = 0.029), satellite nodules (HR 3.29, 95% CI:1.35-8.02, p = 0.029), and vascular encasement (HR 2.63, 95% CI 1.28-5.41, p = 0.029). Additionally, with each increase in axial si...Continue Reading

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Citations

Nov 18, 2018·Clinical and Molecular Hepatology·Woo Kyoung JeongDavid Shinkuo Lu
Feb 23, 2019·European Radiology·Myeong-Jin KimChansik An
Apr 14, 2020·Gastroenterology Report·Wenmo HuYilei Mao
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May 3, 2019·Abdominal Radiology·Zuhir BodalalRegina Beets-Tan
Jan 5, 2020·Insights Into Imaging·Roberto Lo GulloKatja Pinker
Jul 6, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Michael J KingSara Lewis
Dec 29, 2018·Diagnostics·Aman SainiRahmi Oklu
Aug 31, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Fabian BartschHauke Lang

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