Intrahepatic cholestasis in subclinical and overt hyperthyroidism: two case reports.

Journal of Medical Case Reports
Aliye SoyluA Baki Kumbasar

Abstract

Non-specific abnormalities in liver function tests might accompany the clinical course of hyperthyroidism. Hyperthyroidism can cause the elevation of hepatic enzymes and bilirubin. Jaundice is rare in overt hyperthyroidism, especially in subclinical hyperthyroidism. On the other hand, the use of anti-thyroid drugs has rarely been associated with toxic hepatitis and cholestatic jaundice. Here we present two cases of cholestasis that accompanied two distinct forms of clinical hyperthyroidism. The first patient had a clinical presentation of severe cholestasis in the absence of congestive failure related to hyperthyroidism. The second case had developed intrahepatic cholestasis in the presence of subclinical hyperthyroidism, and improved with rifampicin treatment. Hyperthyroidism should be a consideration in non-specific liver dysfunction.

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Citations

Aug 30, 2008·Current Heart Failure Reports·Peter DahlIrwin Klein
Aug 1, 2009·Clinical Journal of Gastroenterology·Hitoshi IchikawaToshifumi Hibi
Apr 7, 2009·Nature Reviews. Gastroenterology & Hepatology·Paola LoriaAmedeo Lonardo
May 16, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Lamia GargouriAbdelmajid Mahfoudh
Mar 18, 2020·The Pan African Medical Journal·Dayssem KhelifiKarima Khiari
Jul 7, 2017·Digestive Diseases and Sciences·Chinemerem J OkwaraDenis McCarthy
Jan 26, 2021·ACG Case Reports Journal·Metri HaddadenMamon Tahhan

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Methods Mentioned

BETA
biopsy
imaging techniques
biopsies

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