Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Anna GlantzLars-Ake Mattsson

Abstract

Intrahepatic cholestasis of pregnancy (ICP), characterized by pruritus in the second half of pregnancy, entails an increased risk to the fetus. This study was designed to determine the incidence and fetal complication rates in ICP, and to define groups at increased risk. In an prospective cohort study conducted between February 1, 1999, and January 31, 2002, all 45,485 pregnancies in a defined region of Sweden (Västra Götaland) were screened for ICP, defined as otherwise unexplained pruritus of pregnancy in combination with fasting serum bile acid levels > or = 10 micromol/L. Pruritus was reported by 937 (2.1%) women, and ICP was diagnosed in 693 (1.5%). Simple logistic regression analyses showed that the probability of fetal complications (spontaneous preterm deliveries, asphyxial events, and meconium staining of amniotic fluid, placenta, and membranes) increased by 1%-2% per additional micromol/L of serum bile acids. Complementary analyses showed that fetal complications did not arise until bile acid levels were > or = 40 micromol/L. Gallstone disease and a family history of ICP were significantly (P < .001) more prevalent in the group of ICP patients with higher bile acid levels. In conclusion, we found an incidence of ICP i...Continue Reading

References

Jul 1, 1991·The British Journal of Dermatology·D Kemmett, M J Tidman
Jul 1, 1989·Journal of Hepatology·M C GonzalezS Arce
Nov 1, 1988·British Journal of Obstetrics and Gynaecology·N M Fisk, G N Storey
Aug 1, 1988·The Australian & New Zealand Journal of Obstetrics & Gynaecology·N M FiskG N Storey
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·G A CamposE J Israel
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·B BergN Tryding
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·E J IsraelG A Campos
Jan 27, 1973·The Medical Journal of Australia·R Rencoret, H Aste
Apr 1, 1984·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T Laatikainen, A Tulenheimo
Mar 15, 1982·American Journal of Obstetrics and Gynecology·D ShawM Willms
Mar 1, 1994·American Journal of Obstetrics and Gynecology·A J RiosecoA M Germain
Oct 1, 1996·American Journal of Obstetrics and Gynecology·O M AlsulymanT M Goodwin
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BacqF Dubois
Oct 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D BritesR Silva
Jun 26, 2001·Journal of the American Academy of Dermatology·G Kroumpouzos, L M Cohen
Feb 15, 2002·Fetal Diagnosis and Therapy·Sean C BlackwellYoram Sorokin
May 30, 2002·Annals of Surgery·Attila NakeebHenry A Pitt
Mar 12, 2003·Current Treatment Options in Gastroenterology·Frank LammertSiegfried Matern
Oct 2, 2003·American Journal of Obstetrics and Gynecology·Alfredo M GermainJuan C Glasinovic

❮ Previous
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Citations

Nov 16, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C M Ambros-Rudolph
Mar 27, 2009·Archives of Gynecology and Obstetrics·Deniz OztekinSivekar Tinar
Jun 4, 2010·Archives of Gynecology and Obstetrics·Hani A Al ShobailiSalah R Ahmad
Aug 3, 2012·Archives of Gynecology and Obstetrics·Vanita SuriK K Kohli
Jun 19, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hui ChenJing Li
Apr 18, 2008·Current Gastroenterology Reports·Grace L Su
Nov 12, 2013·Best Practice & Research. Clinical Obstetrics & Gynaecology·Geethanjali Boregowda, Hassan A Shehata
Feb 18, 2010·Lancet·Deepak JoshiMichael A Heneghan
Mar 29, 2008·Expert Reviews in Molecular Medicine·Marco ArreseJose J G Marin
Dec 25, 2013·The American Journal of Gastroenterology·Peter H DixonCatherine Williamson
May 30, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rick GreupinkFrans G M Russel
Oct 11, 2005·Critical Care Medicine·Saketh R Guntupalli, Jay Steingrub
Apr 9, 2005·Current Opinion in Gastroenterology·Daniel S Pratt
Feb 4, 2010·Current Opinion in Obstetrics & Gynecology·Jonathan K Mays
Oct 24, 2013·Menopause : the Journal of the North American Menopause Society·Kaisa TurunenMarkku Sumanen
Jul 28, 2010·Clinical Obstetrics and Gynecology·Jaclyn Coletta, Lynn L Simpson
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Mohamad H ImamKeith D Lindor
Aug 13, 2013·The Journal of Clinical Investigation·Georgia PapacleovoulouCatherine Williamson
May 19, 2009·BMC Pregnancy and Childbirth·Vinita GurungJim Thornton
May 31, 2007·Orphanet Journal of Rare Diseases·Thomas Pusl, Ulrich Beuers
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chunfang WangXiaotian Li
Dec 7, 2007·Journal of Perinatal Medicine·William M HuangNorman B Javitt
Oct 16, 2008·World Journal of Gastroenterology : WJG·Jurate Kondrackiene, Limas Kupcinskas
Nov 26, 2008·World Journal of Gastroenterology : WJG·Maud LemoineNathalie Ganne-Carrie
May 7, 2009·World Journal of Gastroenterology : WJG·Victoria Geenes, Catherine Williamson
Feb 21, 2009·World Journal of Gastroenterology : WJG·Rocio I R MaciasMaria A Serrano
Nov 28, 2013·World Journal of Gastroenterology : WJG·Khulood T AhmedJamal A Ibdah
Jan 1, 2008·Indian Journal of Dermatology·Silonie Sachdeva
Jan 10, 2014·The American Journal of Gastroenterology·Gwilym J WebbGideon M Hirschfield
Jan 22, 2009·Obstetrics and Gynecology·Richard H LeeT Murphy Goodwin
Apr 9, 2014·BioMed Research International·Julien Lambert
Jan 10, 2014·International Journal of Critical Illness and Injury Science·Indu Lata
Apr 5, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·E PonceletG Chêne
Apr 9, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jianbo ChenMin Ding
Jun 6, 2014·Obstetrics and Gynecology·Catherine Williamson, Victoria Geenes
Jan 28, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marcus MartineauCatherine Williamson
Dec 3, 2014·Clinics in Liver Disease·Priya Kathpalia, Joseph Ahn
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Ashish GoelChundamannil E Eapen

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