PMID: 8970582Nov 1, 1996Paper

Intrahepatic metastases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel

Clinical & Experimental Metastasis
M MitsunobuN Nakao

Abstract

The mechanism and pathogenesis of the high frequency of intrahepatic metastasis in hepatocellular carcinoma (HCC) has not yet been elucidated. Two hundred and thirty one tumors (< or = 5 cm in diameter) of resected specimens of HCC were examined for the relationship between mode of tumor spread and tumor size. Efferent vessels in HCC were identified by direct injection of radiopaque material into the tumor in 23 resected liver specimens selected at random from the 231 tumors. The most frequent site for tumor spread in HCC was capsular invasion followed by extracapsular invasion, vascular invasion, and finally intrahepatic metastasis. There was a strong statistical correlation between the presence of intrahepatic metastasis and the frequency of vascular invasion (correlation coefficient = 0.998). Radiopaque material injected directly into 23 resected tumors entered only the portal vein in 17 tumors and into both the portal and hepatic veins in six tumors. In all eight patients with unresectable lesions, radiopaque media injected percutaneously into tumor nodules flowed only into the portal vein. These findings suggest that tumor spread in HCC progresses from capsular invasion to intrahepatic invasion and that the portal vein may...Continue Reading

References

Sep 1, 1975·American Journal of Surgery·I HonjoO Kitamura
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K WakasaC Kuroda
May 1, 1973·The Journal of Pathology·P P Anthony
May 2, 1974·The New England Journal of Medicine·E T Mays, C S Wheeler
May 1, 1981·Cancer·J G FortnerE J Beattie
Jun 1, 1964·Cancer·R B PATTON, R C HORN

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Citations

Aug 21, 2008·Clinical & Experimental Metastasis·Takashi SuginoToshimitsu Suzuki
Nov 14, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alfredo GuglielmiCalogero Iacono
Nov 6, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jiwei HuangYong Zeng
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Jason Chia-Hsien Cheng
May 10, 2000·International Journal of Radiation Oncology, Biology, Physics·J C ChengC F Horng
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·J SeongC O Suh
Nov 15, 2012·Annals of Surgical Oncology·Manuel Rodríguez-PerálvarezAndrew Kenneth Burroughs
Feb 16, 2012·International Journal of Nanomedicine·Jian-Min QinHe-Bai Shen
Nov 25, 2000·AJR. American Journal of Roentgenology·S K AnJ H Park
Oct 7, 2008·World Journal of Gastroenterology : WJG·Bo ZhaiHong-Yang Wang
Jan 1, 2014·World Journal of Surgery·Nazario PortolaniStefano Maria Giulini
Sep 29, 2011·World Journal of Surgical Oncology·Kensuke MiyazakiSusumu Eguchi
Mar 27, 2010·Digestive Diseases and Sciences·Giulia MalaguarneraMariano Malaguarnera
Aug 1, 2009·Clinical Journal of Gastroenterology·Kenichirou OnukiMasayuki Nakano
Nov 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hua TianJinjun Li
Aug 1, 2012·Seminars in Oncology·Gaetano BertinoGiuseppe Stefano Calvagno
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·K MurakamiI Saiki
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Myron Schwartz
Dec 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Ming WongIrene Oi-Lin Ng
Sep 12, 2014·International Journal of Cancer. Journal International Du Cancer·Zhouying ZhengXiaoshun He
Feb 28, 2002·Seminars in Ultrasound, CT, and MR·Julio MartínLluis Donoso
May 9, 2003·Surgical Oncology Clinics of North America·Gar-Yang ChauChew-Wun Wu
Feb 21, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuki MorimotoKazuhide Yamamoto
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Munkhzaya ByambaragchaaSeong-Gu Hwang
Feb 18, 2015·BioMed Research International·Li-ping Zhuang, Zhi-qiang Meng
Feb 22, 2002·Japanese Journal of Cancer Research : Gann·Shigeaki SawadaIkuo Saiki
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·S KuriyamaH Fukui
Jun 15, 2006·The American Journal of Gastroenterology·David S KotlyarK Rajender Reddy

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