Intrahepatic sarcomatoid cholangiocarcinoma

BMJ Case Reports
Sara SintraAdélia Simão

Abstract

Sarcomatoid carcinoma is a rare tumour composed of intermingled malignant epithelial and mesenchymal cells, and it has been reported in various organs including the liver. Sarcomatoid cholangiocarcinoma (CCC) is an extremely rare liver primary tumour. Here, we report a case of an elderly man who was admitted to our hospital after head trauma. He performed a head CT that diagnosed cerebral metastasis. On abdominal CT, he presented a 10×8×9 cm-sized hypodense liver mass in the VII and VIII segments, with peripheral enhancement. Histological and immunohistochemical examination of the tumour showed a malignant neoplasm with both carcinomatous and sarcomatous components and positive expression of cytokeratin and vimentin antibodies. The patient was diagnosed with intrahepatic sarcomatoid CCC at an advanced stage and died 45 days after the diagnosis. We emphasise the importance of immunohistochemistry which may provide a clue to proper diagnosis.

References

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Dec 16, 2003·Journal of Gastroenterology·Masaki KaiboriYasuo Kamiyama
May 11, 2010·Journal of Oncology·Shalini MalhotraSrinivasan Madhusudan
Mar 2, 2012·Case Reports in Gastroenterology·Yoshiyuki InoueYoshikazu Yasuda
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May 1, 2012·Korean Journal of Hepato-biliary-pancreatic Surgery·Gum O JungGi Jung Youn
Nov 3, 2015·Clinical and Molecular Hepatology·Hye Min KimYoung Nyun Park

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