Intrahepatic transit time predicts liver fibrosis in patients with chronic hepatitis B: quantitative assessment with contrast-enhanced ultrasonography

Ultrasound in Medicine & Biology
Na LiJiyao Wang

Abstract

We investigated the use of contrast-enhanced ultrasonography (CEUS) with quantitative measurements to assess the stages of liver fibrosis in patients with chronic hepatitis B. One-hundred twenty-two patients with chronic hepatitis B were divided into three groups according to the Scheuer scoring system pathologically and according to clinical evidence: mild fibrosis (S0 and S1, n = 36); moderate fibrosis (S2 and S3, n = 24); and cirrhosis (S4 and clinically typical cirrhosis, n = 62). CEUS of hepatic vessels and parenchyma was performed using the Cadence contrast pulse sequencing technique, with an intravenous bolus injection of a contrast agent (SonoVue). Real-time CEUS imaging of the liver was recorded and analyzed offline. Contrast arrival time, baseline, and peak intensity in the hepatic artery, portal vein, right hepatic vein, and liver parenchyma were used to calculate intrahepatic transit times, hepatic artery to hepatic vein transit time (HA-HVTT) and portal vein to hepatic vein transit time (PV-HVTT), as well as increased signal intensity (ISI). The correlations between these quantitative parameters and the stages of fibrosis were analyzed using Spearman rank correlation coefficients. HA-HVTT and PV-HVTT were shortened...Continue Reading

References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Jan 1, 1995·Journal of Hepatology·P J Scheuer
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C Rockey, R A Weisiger
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F CadranelF Degos
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SaadehK Easley
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T PostertW Wilkening
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Jan 28, 2003·Journal of Hepatology·Rekha Rozario, Banumathi Ramakrishna
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Nov 5, 2003·Ultrasound in Medicine & Biology·Jens EydingThomas Postert
Dec 31, 2003·Ultrasound in Medicine & Biology·Olivier LucidarmeRobert F Mattrey
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F LokUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases (AASLD)
Feb 9, 2005·European Radiology·Patrick Phillips, Edward Gardner
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Masashi HirotaAkimasa Nakao
Aug 9, 2005·Ultrasound in Medicine & Biology·Christos KrogiasJens Eyding
May 25, 2006·Radiology·Adrian K P LimMartin J K Blomley
Sep 26, 2006·Human Pathology·Jeanne SerpaggiStanislas Pol
Oct 19, 2006·Ultrasound in Medicine & Biology·Ryo MetokiMasahiko Yamada
Jan 9, 2007·Ultrasound in Medicine & Biology·Kyosuke YanagisawaHiroko Iijima
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masahiko KodaYoshikazu Murawaki
Aug 3, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F RidolfiE Brunelli
Mar 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Carlo FabrisMario Pirisi
Mar 13, 2008·Contrast Media & Molecular Imaging·Susanne M StiegerKatherine W Ferrara
Nov 6, 2008·Clinics in Liver Disease·Massimo Pinzani, Francesco Vizzutti
Oct 14, 2009·Clinical Radiology·N GoyalM Robinson

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Citations

Jul 20, 2012·Der Radiologe·E M JungD-A Clevert
Sep 1, 2011·Abdominal Imaging·Carlos Nicolau, Tomás Ripollés
Feb 19, 2019·Clinical and Molecular Hepatology·Hitoshi Maruyama, Naoya Kato
Jan 7, 2015·World Journal of Gastroenterology : WJG·Maurizio SoresiGiuseppe Montalto
Nov 12, 2015·World Journal of Gastroenterology : WJG·Yoav LurieGerardo Z Lederkremer
May 13, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jun LiGui-Lin Lu
Apr 29, 2015·World Journal of Gastroenterology : WJG·Lin ZhaiLin-Xue Qian
Jan 31, 2021·Scientific Reports·Lokesh BasavarajappaKenneth Hoyt

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